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Francis G. Spinale
Researcher at University of South Carolina
Publications - 469
Citations - 24683
Francis G. Spinale is an academic researcher from University of South Carolina. The author has contributed to research in topics: Heart failure & Ventricular remodeling. The author has an hindex of 84, co-authored 451 publications receiving 23239 citations. Previous affiliations of Francis G. Spinale include Biogen Idec & Veterans Health Administration.
Papers
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Journal ArticleDOI
Alterations in aortic cellular constituents during thoracic aortic aneurysm development: myofibroblast-mediated vascular remodeling.
Jeffrey A. Jones,Jeffrey A. Jones,Christy Beck,John R. Barbour,Jouzas A. Zavadzkas,Rupak Mukherjee,Francis G. Spinale,Francis G. Spinale,John S. Ikonomidis +8 more
TL;DR: In this article, aortic dilatation was accompanied by changes in the elastic architecture that included a decreased number of elastic lamellae (from 6 to 4), altered area fraction of elastin (elevated at 4 weeks and decreased at 16 weeks).
Journal ArticleDOI
Calpain inhibition preserves myocardial structure and function following myocardial infarction.
Santhosh K. Mani,Sundaravadivel Balasubramanian,Juozas A. Zavadzkas,Laura B Jeffords,William T Rivers,Michael R. Zile,Rupak Mukherjee,Francis G. Spinale,Dhandapani Kuppuswamy +8 more
TL;DR: It is indicated that calpain contributes to MI-induced alterations in myocardial structure and function and that it could be a potential therapeutic target in treating MI patients.
Journal ArticleDOI
Cellular and molecular alterations in the β adrenergic system with cardiomyopathy induced by tachycardia
Francis G. Spinale,George E Tempel,Rupak Mukherjee,D. M. Eble,R. D. Brown,Charles A. Vacchiano,Michael R. Zile +6 more
TL;DR: The changes in myocyte beta adrenergic responsiveness with the development of tachycardic cardiomyopathy are due to alterations in cellular mechanisms (decreased beta receptor and Gs density, increased Gi) and in molecular mechanisms (increased Gi mRNA content).
Changes inDiastolic Function During Development andCorrection ofChronic LVVolumeOverload Produced by Mitral Regurgitation
TL;DR: The enhanced diastolic function seen in chronic MR returned to normal after correction of the chronic volume overload by MVR.
Journal ArticleDOI
Effects of Growth Hormone Supplementation on Left Ventricular Morphology and Myocyte Function With the Development of Congestive Heart Failure
Ward V. Houck,L. C. Pan,Scott B. Kribbs,Mark J. Clair,G M McDaniel,R S Krombach,W. M. Merritt,C. Pirie,Julie P. Iannini,Rupak Mukherjee,Francis G. Spinale +10 more
TL;DR: Short-term GH supplementation improved LV pump function in pacing CHF as a result of favorable effects on LV remodeling and contractile processes, and GH supplementation may serve as a novel therapeutic modality in developing CHF.