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Francis G. Spinale
Researcher at University of South Carolina
Publications - 469
Citations - 24683
Francis G. Spinale is an academic researcher from University of South Carolina. The author has contributed to research in topics: Heart failure & Ventricular remodeling. The author has an hindex of 84, co-authored 451 publications receiving 23239 citations. Previous affiliations of Francis G. Spinale include Biogen Idec & Veterans Health Administration.
Papers
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Journal ArticleDOI
Concomitant Endothelin Receptor Subtype-A Blockade During the Progression of Pacing-Induced Congestive Heart Failure in Rabbits Beneficial Effects on Left Ventricular and Myocyte Function
Francis G. Spinale,Jennifer D. Walker,Rupak Mukherjee,Julie P. Iannini,Anthony T. Keever,Kim P. Gallagher +5 more
TL;DR: The results from this study suggest that chronically elevated ET-1 levels and subsequent activation of the ETA receptor play a direct and contributory role in the progression of the CHF process and specific ETA receptors blockade may provide a new and useful therapeutic modality in the setting of CHF.
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Matrix metalloproteinase synthesis and expression in isolated LV myocyte preparations
TL;DR: It is demonstrated for the first time that adult LV myocytes synthesize and express members of the MMP family and thus may potentially participate in the LV remodeling process through synthesis and secretion of MMPs.
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Selective Targeting and Timing of Matrix Metalloproteinase Inhibition in Post-Myocardial Infarction Remodeling
William M. Yarbrough,Rupak Mukherjee,G. Patricia Escobar,Joseph T. Mingoia,Jeffrey A. Sample,Jennifer W. Hendrick,Kathryn B. Dowdy,Julie E. McLean,Abigail S. Lowry,Timothy P. O’Neill,Francis G. Spinale +10 more
TL;DR: Inhibition of MMP-1 and −7 is not required to favorably influence LV remodeling after MI and a temporal difference exists with respect to the timing of sMMPi and regional and global myocardial remodeling patterns after MI.
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Inhibition of collagen cross-linking: effects on fibrillar collagen and ventricular diastolic function
TL;DR: The fibrillar collagen network is postulated to be a primary determinant of left ventricular diastolic stiffness by examining the structural and physiological effects of a reduction in fibrilar collagen content and cross-linking in the intact left ventricle by treating five normal adult pigs with beta-aminopropionitrile.
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TNF-α and myocardial matrix metalloproteinases in heart failure: relationship to LV remodeling
William S Bradham,Gordon W. Moe,Katherine A. Wendt,Amelia A. Scott,Andrea Konig,Marina Romanova,George O.A. Naik,Francis G. Spinale +7 more
TL;DR: The cytokine tumor necrosis factor (TNF)-α has been causally linked to left ventricular (LV) remodeling, but the molecular basis for this effect is unknown.