F
Francis S. Willard
Researcher at Eli Lilly and Company
Publications - 97
Citations - 5904
Francis S. Willard is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Heterotrimeric G protein & G protein-coupled receptor. The author has an hindex of 39, co-authored 93 publications receiving 5249 citations. Previous affiliations of Francis S. Willard include University of North Carolina at Chapel Hill & Australian National University.
Papers
More filters
Journal ArticleDOI
G-protein signaling: back to the future
Christopher R. McCudden,Melinda D. Hains,Randall J. Kimple,David P. Siderovski,Francis S. Willard +4 more
TL;DR: In this paper, the authors revisited classical heterotrimeric G-protein signaling and explored these new, non-canonical Gprotein signaling pathways, including a receptor-independent Gα nucleotide cycle that regulates cell division.
Journal ArticleDOI
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits.
TL;DR: More recent discoveries that have highlighted newly-appreciated roles for RGS proteins beyond mere negative regulators of 7TM signaling are reviewed, including the RGS-box-containing, RhoA-specific guanine nucleotide exchange factors (RGS-RhoGEFs) that serve as Gα effectors to couple 7TM and semaphorin receptor signaling to RHoA activation.
Journal ArticleDOI
A Seven-Transmembrane RGS Protein That Modulates Plant Cell Proliferation
Jin-Gui Chen,Francis S. Willard,Jirong Huang,Jiansheng Liang,Scott A. Chasse,Alan M. Jones,David P. Siderovski +6 more
TL;DR: An RGS protein (AtRGS1) in Arabidopsis that has a predicted structure similar to a GPCR as well as an RGS box with GTPase accelerating activity is identified, suggesting that AtRGS 1 is a critical modulator of plant cell proliferation.
Journal ArticleDOI
Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos.
Kelly Colombo,Stephan W. Grill,Randall J. Kimple,Francis S. Willard,David P. Siderovski,Pierre Gönczy +5 more
TL;DR: The extent of net pulling forces may depend on cortical Gα activity, which is regulated by anterior-posterior polarity cues through GPR-1/2, which was found to interact with guanosine diphosphate-bound GOA-1 and were enriched on the posterior cortex in a par-3– and par-2–dependent manner.
Journal ArticleDOI
Crystal structure of the human PRMT5:MEP50 complex
Stephen Antonysamy,Zahid Quyoom Bonday,Robert M. Campbell,Brandon Doyle,Zhanna Druzina,Tarun Gheyi,Bomie Han,Louis Nickolaus Jungheim,Yuewei Qian,Charles Rauch,Marijane Russell,J. Michael Sauder,S.R. Wasserman,Kenneth Weichert,Francis S. Willard,Aiping Zhang,S. Emtage +16 more
TL;DR: The crystal structure of human PRMT5 in complex with MEP50, bound to an S-adenosylmethionine analog and a peptide substrate derived from histone H4 is determined and the structure of the surprising hetero-octameric complex reveals the close interaction between the seven-bladed β-propeller MEP50 and the N-terminal domain ofPRMT5, and delineates the structural elements of substrate recognition.