Maria S. Robles

TL;DR: Large-scale proteomic analysis of the proteome in the mouse liver revealed a high temporal coordination in the abundance of proteins involved in the same metabolic process, such as xenobiotic detoxification, and revealed many other essential cellular processes in which protein levels are under circadian control.

TL;DR: Analysis of protein constituents of PER complexes purified from mouse tissues and identified PSF indicates that PSF within the PER complex recruits SIN3A, a scaffold for assembly of transcriptional inhibitory complexes and that the Per complex thereby rhythmically delivers histone deacetylases to the Per1 promoter, which repress Per1 transcription.

TL;DR: The data indicate a dominant regulatory role for phosphorylation-dependent circadian tuning of signaling pathways, which allows the organism to integrate different signals and rapidly and economically respond to daily changes in nutrient availability and physiological states.

TL;DR: CircaInSilico is introduced, a web-based application for generating synthetic genome biology data to benchmark statistical methods for studying biological rhythms, and several unmet analytical needs, including applications to clinical medicine, are discussed and productive avenues to address them are suggested.

TL;DR: It is proposed that the circadian clock PERIOD proteins optimize mitochondrial metabolism to daily changes in energy supply/demand and thereby, serve as a rheostat for mitochondrial nutrient utilization.