S
Stephen R. Brooks
Researcher at National Institutes of Health
Publications - 64
Citations - 5146
Stephen R. Brooks is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Proinflammatory cytokine. The author has an hindex of 26, co-authored 54 publications receiving 3453 citations. Previous affiliations of Stephen R. Brooks include University of Alabama at Birmingham & United States Department of Energy Office of Science.
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Journal ArticleDOI
Activated STING in a Vascular and Pulmonary Syndrome
Yongmei Liu,A Almeida de Jesus,B Marrero,Dan Yang,Suzanne E. Ramsey,Suzanne E. Ramsey,G.A. Montealegre Sanchez,Klaus Tenbrock,Klaus Tenbrock,Helmut Wittkowski,Helmut Wittkowski,Olcay Y. Jones,Olcay Y. Jones,Hye Sun Kuehn,Chyi-Chia Richard Lee,Michael A. DiMattia,Edward W. Cowen,Benito Gonzalez,Ira Palmer,J.J. DiGiovanna,Angelique Biancotto,H. Kim,Wanxia L. Tsai,Anna M. Trier,Yhu Chering Huang,Deborah L. Stone,S Hill,Hanna Kim,C. St. Hilaire,Shakuntala Gurprasad,Nicole Plass,D. Chapelle,Iren Horkayne-Szakaly,Iren Horkayne-Szakaly,Dirk Foell,Dirk Foell,Andrei Barysenka,Andrei Barysenka,Fabio Candotti,Steven M. Holland,Jason D. Hughes,Jason D. Hughes,Huseyin Mehmet,Huseyin Mehmet,Andrew C. Issekutz,Andrew C. Issekutz,Mark Raffeld,Joshua J McElwee,Joshua J McElwee,Joseph R. Fontana,Caterina P. Minniti,Susan Moir,Daniel L. Kastner,Massimo Gadina,A.C. Steven,Paul T. Wingfield,Stephen R. Brooks,Sofia Rosenzweig,Thomas A. Fleisher,Zuoming Deng,Manfred Boehm,Amy S. Paller,Amy S. Paller,Raphaela Goldbach-Mansky +63 more
TL;DR: STING-associated vasculopathy with onset in infancy (SAVI) is an autoinflammatory disease caused by gain-of-function mutations in TMEM173, the stimulator of interferon genes (STING), andConstitutive up-regulation of phosphorylated STAT1 in patients' lymphocytes was reduced by JAK inhibitors.
Journal ArticleDOI
An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
Scott W. Canna,Adriana Almeida de Jesus,Sushanth Gouni,Stephen R. Brooks,Bernadette Marrero,Yin Liu,Michael A. DiMattia,Kristien J. M. Zaal,Gina A. Montealegre Sanchez,Hanna Kim,Dawn Chapelle,Nicole Plass,Yan Huang,Alejandro V. Villarino,Angelique Biancotto,Thomas A. Fleisher,Joseph A. Duncan,John J. O'Shea,Susanne M. Benseler,Alexei A. Grom,Zuoming Deng,Ronald M. Laxer,Raphaela Goldbach-Mansky +22 more
TL;DR: A new monoallelic inflammasome defect is described that expands the monogenic autoinflammatory disease spectrum to include MAS and suggests new targets for therapy.
Journal ArticleDOI
Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.
David B. Beck,Marcela A. Ferrada,Keith A. Sikora,Amanda K. Ombrello,Jason C. Collins,Wuhong Pei,Nicholas Balanda,Daron L. Ross,Daniela Ospina Cardona,Zhijie Wu,Bhavisha A Patel,Kalpana Manthiram,Emma M. Groarke,Fernanda Gutierrez-Rodrigues,Patrycja Hoffmann,Sofia Rosenzweig,Shuichiro Nakabo,Laura W. Dillon,Christopher S. Hourigan,Wanxia L. Tsai,Sarthak Gupta,Carmelo Carmona-Rivera,Anthony J. Asmar,Lisha Xu,Hirotsugu Oda,Wendy Goodspeed,Karyl S. Barron,Michele Nehrebecky,Anne Jones,Ryan S. Laird,Natalie Deuitch,Dorota Rowczenio,Emily Rominger,Kristina V. Wells,Chyi-Chia Richard Lee,Weixin Wang,Megan Trick,James C. Mullikin,Gustaf Wigerblad,Stephen R. Brooks,Stefania Dell'Orso,Zuoming Deng,Jae Jin Chae,Alina Dulau-Florea,May Christine V. Malicdan,Danica Novacic,Robert A. Colbert,Mariana J. Kaplan,Massimo Gadina,Sinisa Savic,Helen J. Lachmann,Mones Abu-Asab,Benjamin D. Solomon,Kyle Retterer,William A. Gahl,Shawn M. Burgess,Ivona Aksentijevich,Neal S. Young,Katherine R. Calvo,Achim Werner,Daniel L. Kastner,Peter C. Grayson +61 more
TL;DR: Using a genotype-driven approach, this disorder is identified that connects seemingly unrelated adult-onset inflammatory syndromes and is named the VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome.
Journal ArticleDOI
JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies
Gina A. Montealegre Sanchez,Adam L Reinhardt,Suzanne E. Ramsey,Helmut Wittkowski,Philip J. Hashkes,Yackov Berkun,Susanne Schalm,Sara Murias,Jason Dare,Diane Brown,Deborah L. Stone,Ling Gao,Thomas Klausmeier,Dirk Foell,Adriana Almeida de Jesus,Dawn Chapelle,Hanna Kim,Samantha Dill,Robert A. Colbert,Laura Failla,B. Kost,Michelle O'Brien,James C. Reynolds,Les R. Folio,Katherine R. Calvo,Scott M. Paul,Nargues Weir,Alessandra Brofferio,Ariane Soldatos,Angelique Biancotto,Edward W. Cowen,John J. Digiovanna,Massimo Gadina,Andrew Lipton,Colleen Hadigan,Steven M. Holland,Joseph A. Fontana,Ahmad Samer Alawad,Rebecca J. Brown,Kristina I. Rother,Theo Heller,Kristina M Brooks,Parag Kumar,Stephen R. Brooks,Meryl Waldman,Harsharan K. Singh,Volker Nickeleit,Maria Silk,Apurva Prakash,Jonathan Janes,Seza Ozen,Paul G. Wakim,Paul A. Brogan,William L. Macias,Raphaela Goldbach-Mansky +54 more
TL;DR: Upon baricitinib treatment, clinical manifestations and inflammatory and IFN biomarkers improved in patients with the monogenic interferonopathies CANDLE, SAVI, and other interfer onopathies.
Journal ArticleDOI
Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality
Han-Yu Shih,Giuseppe Sciumè,Yohei Mikami,Liying Guo,Hong-Wei Sun,Stephen R. Brooks,Joseph F. Urban,Fred P. Davis,Yuka Kanno,John J. O'Shea +9 more
TL;DR: It is found that chromatin in proximity to effector genes is selectively accessible in ILCs prior to high-level transcription upon activation, which indicates extensive sharing of regulatory circuitry across the innate and adaptive compartments of the immune system, in spite of their divergent developing pathways.