P
Panpan Zhou
Researcher at Tsinghua University
Publications - 22
Citations - 550
Panpan Zhou is an academic researcher from Tsinghua University. The author has contributed to research in topics: Antibody & Medicine. The author has an hindex of 6, co-authored 7 publications receiving 189 citations.
Papers
More filters
Journal ArticleDOI
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection
Panpan Zhou,Meng Yuan,Ge Song,Nathan Beutler,Namir Shaabani,Deli Huang,Wan-ting He,Xu-Dong Zhu,Sean Callaghan,Peter Yong,Fabio Anzanello,Linghang Peng,James Ricketts,Mara Parren,Elijah Garcia,Stephen A. Rawlings,Davey M. Smith,David Nemazee,John R. Teijaro,Thomas F. Rogers,Ian A. Wilson,Dennis R. Burton,Raiees Andrabi +22 more
TL;DR: The authors identified a human monoclonal antibody isolated from a convalescent donor, CC40.8, that bound to the SARS-CoV-2 S2 stem peptide, a region that is conserved across beta-coronaviruses.
Journal ArticleDOI
Ultrapotent Human Neutralizing Antibody Repertoires Against Middle East Respiratory Syndrome Coronavirus From a Recovered Patient
Peihua Niu,Senyan Zhang,Panpan Zhou,Baoying Huang,Yao Deng,Kun Qin,Pengfei Wang,Wenling Wang,Xinquan Wang,Jianfang Zhou,Linqi Zhang,Wenjie Tan +11 more
TL;DR: The MERS-CoV-neutralizing antibody repertoires from a survivor are described and 13 ultrapotent mAbs are characterized, including two mAbs that exhibited the strongest neutralizing activities.
Journal ArticleDOI
Delineating antibody recognition against Zika virus during natural infection
Lei Yu,Ruoke Wang,Fei Gao,Li Min,Jianying Liu,Jian Wang,Wenxin Hong,Lingzhai Zhao,Yingfen Wen,Chibiao Yin,Hua Wang,Qi Zhang,Yangyang Li,Panpan Zhou,Rudian Zhang,Yang Liu,Xiaoping Tang,Yongjun Guan,Cheng-Feng Qin,Ling Chen,Xuanling Shi,Xia Jin,Gong Cheng,Fuchun Zhang,Linqi Zhang +24 more
TL;DR: The most potent neutralizing mAb targeting the DIII provided 100% protection in mice from lethal ZIKV infection and could therefore serve as a promising candidate for antibody-based therapy and prevention.
Journal ArticleDOI
Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein
Senyan Zhang,Panpan Zhou,Pengfei Wang,Yangyang Li,Liwei Jiang,Wenxu Jia,Han Wang,Angela Fan,Dongli Wang,Xuanling Shi,Xianyang Fang,Michal Hammel,Shuying Wang,Xinquan Wang,Xinquan Wang,Linqi Zhang +15 more
TL;DR: This work reports a unique epitope and unusual neutralizing mechanism of the isolated human antibody MERS-4 that provides a valuable addition for the combined use of antibodies against Mers-CoV infection.
Journal ArticleDOI
Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection
Wenxu Jia,Rudragouda Channappanavar,Chao Zhang,Mingxi Li,Haixia Zhou,Shuyuan Zhang,Panpan Zhou,Jiuyang Xu,Sisi Shan,Xuanling Shi,Xinquan Wang,Jincun Zhao,Dongming Zhou,Stanley Perlman,Linqi Zhang +14 more
TL;DR: Results show that AdC68-S can induce protective immune responses in mice and represent a promising candidate for further development against MERS-CoV infection in both dromedaries and humans.