George Newport

TL;DR: Computational methods are developed to assemble a diploid genome sequence in good agreement with available physical mapping data and provide a whole-genome description of heterozygosity in the organism.

TL;DR: Improved annotation permitted a detailed analysis of several multigene families, and comparative genomic studies showed that C. albicans has a far greater catabolic range, encoding respiratory Complex 1, several novel oxidoreductases and ketone body degrading enzymes, malonyl- CoA and enoyl-CoA carriers, and numerous transporters to assimilate the resulting nutrients.

TL;DR: An application of a custom Affymetrix GeneChip representative of the entire C. albicans genome and assay the global expression profiles of white and opaque switch phenotypes of the WO-1 strain extends the understanding of strategies used in microbial phase variation and pathogenesis and further characterize the unanticipated diversity of genes expressed in phenotypes.

TL;DR: Using a custom Affymetrix GeneChip© representing the entire Candida albicans genome, the changes in genome‐wide gene expression in this opportunistic pathogen are examined as a function of alterations in environmental concentrations of iron to expand the understanding of global iron regulation in C. al bicans and provide insights into the potential role of iron availability.

TL;DR: This is the first detailed study showing that the SAP gene family is expressed by C. albicans during colonization and infection in humans and that C.Albicans infection is associated with the differential expression of individualSAP genes which may be involved in the pathogenesis of oral candidiasis.