G
Georgios Nikitas
Researcher at French Institute of Health and Medical Research
Publications - 7
Citations - 1520
Georgios Nikitas is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Listeria monocytogenes & Virulence. The author has an hindex of 5, co-authored 5 publications receiving 1420 citations. Previous affiliations of Georgios Nikitas include World Health Organization & Pasteur Institute.
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Journal ArticleDOI
The Listeria transcriptional landscape from saprophytism to virulence
Alejandro Toledo-Arana,Olivier Dussurget,Olivier Dussurget,Olivier Dussurget,Georgios Nikitas,Georgios Nikitas,Nina Sesto,Nina Sesto,Nina Sesto,Hélène Guet-Revillet,Hélène Guet-Revillet,Hélène Guet-Revillet,Damien Balestrino,Damien Balestrino,Damien Balestrino,Edmund Loh,Jonas Gripenland,Teresa Tiensuu,Karolis Vaitkevicius,Mathieu Barthelemy,Massimo Vergassola,Massimo Vergassola,Marie-Anne Nahori,Marie-Anne Nahori,Marie-Anne Nahori,Guillaume Soubigou,Béatrice Regnault,Jean-Yves Coppée,Marc Lecuit,Jörgen Johansson,Pascale Cossart,Pascale Cossart,Pascale Cossart +32 more
TL;DR: Using tiling arrays and RNAs from wild-type and mutant bacteria grown in vitro, ex vivo and in vivo, the transcription of its entire genome is analysed and it is discovered that riboswitches can act as terminators for upstream genes.
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Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis
Olivier Disson,Olivier Disson,Solène Grayo,Solène Grayo,Eugénie Huillet,Eugénie Huillet,Eugénie Huillet,Georgios Nikitas,Georgios Nikitas,Francina Langa-Vives,Olivier Dussurget,Olivier Dussurget,Olivier Dussurget,Marie Ragon,Alban Le Monnier,Charles Babinet,Pascale Cossart,Pascale Cossart,Pascale Cossart,Marc Lecuit +19 more
TL;DR: Using the gerbil, a natural host for L. monocytogenes, and a knock-in mouse line ubiquitously expressing humanized E-cadherin, the essential and interdependent roles of InlA and InlB in fetoplacental listeriosis are uncovered and the molecular mechanism underlying the ability of a microbe to target and cross the placental barrier is deciphered.
Journal ArticleDOI
Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin
Georgios Nikitas,Chantal Deschamps,Chantal Deschamps,Olivier Disson,Olivier Disson,Théodora Niault,Théodora Niault,Pascale Cossart,Pascale Cossart,Marc Lecuit,Marc Lecuit,Marc Lecuit +11 more
TL;DR: Listeria monocytogenes targets accessible E-cadherin expressed on mucus-producing goblet cells to invade the intestinal tissue.
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Identity, regulation and in vivo function of gut NKp46+RORγt+ and NKp46+RORγt- lymphoid cells.
Ana Reynders,Ana Reynders,Nadia Yessaad,Nadia Yessaad,Thien-Phong Vu Manh,Thien-Phong Vu Manh,Marc Dalod,Marc Dalod,Aurore Fenis,Aurore Fenis,Camille Aubry,Camille Aubry,Camille Aubry,Georgios Nikitas,Georgios Nikitas,Bertrand Escalière,Bertrand Escalière,Jean-Christophe Renauld,Olivier Dussurget,Olivier Dussurget,Olivier Dussurget,Pascale Cossart,Pascale Cossart,Pascale Cossart,Marc Lecuit,Marc Lecuit,Marc Lecuit,Eric Vivier,Elena Tomasello,Elena Tomasello +29 more
TL;DR: It is demonstrated that small intestine (SI) NKp46+RORγt− ILCs correspond to SI NK cells and that the IL‐1β/IL‐1R1/MyD88 pathway, but not the commensal flora, drove IL‐22 production by NKp 46+rorγt+ I LCs, which is associated with subset‐specific transcriptional programmes and effector functions that govern their implication in gut innate immunity.
Journal ArticleDOI
Modeling human listeriosis in natural and genetically engineered animals
Olivier Disson,Georgios Nikitas,Georgios Nikitas,Solène Grayo,Solène Grayo,Olivier Dussurget,Olivier Dussurget,Olivier Dussurget,Pascale Cossart,Pascale Cossart,Pascale Cossart,Marc Lecuit +11 more
TL;DR: In this article, the authors present protocols for studying listeriosis in three complementary animal models: (i) the human E-cadherin (hEcad) transgenic mouse line, (ii) the knock-in E16P mouse line; and (iii) the gerbil, in which both InlA and InlB−Met species-specific interactions occur as in humans.