A
Alex Desautels
Researcher at Université de Montréal
Publications - 94
Citations - 4730
Alex Desautels is an academic researcher from Université de Montréal. The author has contributed to research in topics: Sleepwalking & Population. The author has an hindex of 34, co-authored 88 publications receiving 4195 citations. Previous affiliations of Alex Desautels include McGill University.
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Journal ArticleDOI
Narcolepsy is strongly associated with the T-cell receptor alpha locus.
Joachim Hallmayer,Juliette Faraco,Ling Lin,Stephanie Hesselson,Juliane Winkelmann,Minae Kawashima,Minae Kawashima,Geert Mayer,Giuseppe Plazzi,Sona Nevsimalova,Patrice Bourgin,Sheng Seung-Chul Hong,Yutaka Honda,Makoto Honda,Birgit Högl,William T. Longstreth,Jacques Montplaisir,David Kemlink,Mali Einen,Justin Chen,Stacy L. Musone,Matthew Akana,Taku Miyagawa,Jubao Duan,Alex Desautels,Christine Erhardt,Per Egil Hesla,Francesca Poli,Birgit Frauscher,Jong-Hyun Jeong,Sung-Pil Lee,Thanh G.N. Ton,Mark N. Kvale,Libor Kolesar,Marie Dobrovolna,Gerald T. Nepom,Daniel R. Salomon,H-Erich Wichmann,Guy A. Rouleau,Christian Gieger,Douglas F. Levinson,Pablo V. Gejman,Pablo V. Gejman,Thomas Meitinger,Terry Young,Paul E. Peppard,Katsushi Tokunaga,Pui-Yan Kwok,Neil Risch,Neil Risch,Emmanuel Mignot,Emmanuel Mignot +51 more
TL;DR: The authors found association between narcolepsy and polymorphisms in the TRA@ (T-cell receptor alpha) locus, with highest significance at rs1154155 (average allelic odds ratio 1.69, genotypic odds ratios 1.94 and 2.55, P < 10(-21), 1,830 cases, 2,164 controls).
Journal ArticleDOI
Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q.
Alex Desautels,Gustavo Turecki,Jacques Montplaisir,Adolfo Sequeira,Andrei Verner,Guy A. Rouleau +5 more
TL;DR: These findings represent the first mapping of a locus conferring susceptibility to RLS, and positioning the RLS-predisposing gene in a 14.71-cM region between D 12S1044 and D12S78 is refined.
Journal ArticleDOI
Polysomnographic diagnosis of idiopathic REM sleep behavior disorder.
Jacques Montplaisir,Jean-François Gagnon,Maria Livia Fantini,Ronald B. Postuma,Yves Dauvilliers,Alex Desautels,Sylvie Rompré,Jean Paquet +7 more
TL;DR: The diagnostic value of a visual scoring method for the diagnosis of idiopathic RBD is estimated and cut‐off values to be used in clinical and research set‐ups are established.
Journal ArticleDOI
ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy
Juliette Faraco,Ling Lin,Birgitte Rahbek Kornum,Birgitte Rahbek Kornum,Eimear E. Kenny,Gosia Trynka,Mali Einen,Tom Rico,Peter Lichtner,Yves Dauvilliers,Isabelle Arnulf,Michel Lecendreux,Sirous Javidi,Peter Geisler,Geert Mayer,Fabio Pizza,Francesca Poli,Giuseppe Plazzi,Giuseppe Plazzi,Sebastiaan Overeem,Gert Jan Lammers,David Kemlink,Karel Sonka,Sona Nevsimalova,Guy A. Rouleau,Alex Desautels,Jacques Montplaisir,Birgit Frauscher,Laura Ehrmann,Birgit Högl,Poul Jennum,Patrice Bourgin,Rosa Peraita-Adrados,Alex Iranzo,Claudio L. Bassetti,Wei-Min Chen,Patrick Concannon,Susan D. Thompson,Vincent Damotte,Bertrand Fontaine,Maxime Breban,Maxime Breban,Christian Gieger,Norman Klopp,Panos Deloukas,Cisca Wijmenga,Joachim Hallmayer,Suna Onengut-Gumuscu,Stephen S. Rich,Juliane Winkelmann,Emmanuel Mignot +50 more
TL;DR: For example, the authors found that three loci located outside the Human Leukocyte Antigen (HLA) region on chromosome 6 were significantly associated with disease risk, including Cathepsin H (CTSH), Tumor necrosis factor (ligand) superfamily member 4 (TNFSF4), and OX40L.
Journal ArticleDOI
Common variants in P2RY11 are associated with narcolepsy
Birgitte Rahbek Kornum,Minae Kawashima,Minae Kawashima,Juliette Faraco,Ling Lin,Thomas J Rico,Stephanie Hesselson,Robert C. Axtell,Hedwich F. Kuipers,Karin Weiner,Alexandra Hamacher,Matthias U. Kassack,Fang Han,Stine Knudsen,Jing Li,Xiaosong Dong,Juliane Winkelmann,Giuseppe Plazzi,Sona Nevsimalova,Seung-Chul Hong,Yutaka Honda,Makoto Honda,Birgit Högl,Thanh G.N. Ton,Jacques Montplaisir,Patrice Bourgin,David Kemlink,Yu-Shu Huang,Simon C. Warby,Mali Einen,Jasmin L Eshragh,Taku Miyagawa,Alex Desautels,Elisabeth Ruppert,Per Egil Hesla,Francesca Poli,Fabio Pizza,Birgit Frauscher,Jong-Hyun Jeong,Sung-Pil Lee,Kingman P. Strohl,William T. Longstreth,Mark N. Kvale,Marie Dobrovolna,Maurice M. Ohayon,Gerald T. Nepom,H-Erich Wichmann,Guy A. Rouleau,Christian Gieger,Douglas F. Levinson,Pablo V. Gejman,Thomas Meitinger,Paul E. Peppard,Terry Young,Poul Jennum,Lawrence Steinman,Katsushi Tokunaga,Pui-Yan Kwok,Neil Risch,Neil Risch,Joachim Hallmayer,Emmanuel Mignot +61 more
TL;DR: A SNP in the 3′ untranslated region of P2RY11, the purinergic receptor subtype P2Y11 gene, is identified as an important regulator of immune-cell survival, with possible implications in narcolepsy and other autoimmune diseases.