J
Jean-Marie Rakic
Researcher at University of Liège
Publications - 57
Citations - 2609
Jean-Marie Rakic is an academic researcher from University of Liège. The author has contributed to research in topics: Choroidal neovascularization & Angiogenesis. The author has an hindex of 20, co-authored 51 publications receiving 2412 citations. Previous affiliations of Jean-Marie Rakic include Sanofi S.A..
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Journal ArticleDOI
Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization
Jean-Marie Rakic,Vincent Lambert,Laetitia Devy,Aernout Luttun,Peter Carmeliet,Carel Claes,Laurent Nguyen,Jean-Michel Foidart,Agnès Noël,Carine Munaut +9 more
TL;DR: Observations demonstrate the participation of PlGF in experimental CNV and identify therefore PlGF as an additional promising target for ocular antiangiogenic strategies.
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Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice.
Vincent Lambert,Julie Lecomte,Sylvain Hansen,Silvia Blacher,Maria-Luz Alvarez Gonzalez,Ingrid Struman,Nor Eddine Sounni,Eric Rozet,Pascal De Tullio,Jean-Michel Foidart,Jean-Marie Rakic,Agnès Noël +11 more
TL;DR: This standardized protocol can be applied to transgenic mice and can include treatments with drugs, recombinant proteins, antibodies, adenoviruses and pre-microRNAs to aid in the search for new molecular regulators and the identification of novel targets for innovative treatments.
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Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease.
Sara Van de Veire,Ingeborg Stalmans,Femke Heindryckx,Hajimu Oura,Annemilaï Tijeras-Raballand,Thomas Schmidt,Sonja Loges,Imke Albrecht,Bart Jonckx,Stefan Vinckier,Christophe Van Steenkiste,Sonia Tugues,Sonia Tugues,Charlotte Rolny,Maria De Mol,Daniela Dettori,Patricia Hainaud,Lieve Coenegrachts,Jean Olivier Contreres,Tine Van Bergen,Henar Cuervo,Wei Hong Xiao,Carole Le Henaff,Ian Buysschaert,Behzad Kharabi Masouleh,Anja Geerts,Tibor Schomber,Philippe Bonnin,Vincent Lambert,Jurgen Haustraete,Serena Zacchigna,Jean-Marie Rakic,Wladimiro Jiménez,Agnès Noël,Mauro Giacca,Isabelle Colle,Jean-Michel Foidart,Gérard Tobelem,Manuel Morales-Ruiz,José Vilar,Patrick H. Maxwell,Stanley A. Vinores,Stanley A. Vinores,Geert Carmeliet,Mieke Dewerchin,Lena Claesson-Welsh,Evelyne Dupuy,Hans Van Vlierberghe,Gerhard Christofori,Massimiliano Mazzone,Michael Detmar,Desire Collen,Peter Carmeliet +52 more
TL;DR: It is shown that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease and warrant further testing of anti-PlGF therapies.
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MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells.
Céline Sabatel,Ludovic Malvaux,Nicolas Bovy,Christophe Deroanne,Vincent Lambert,Maria-Luz Alvarez Gonzalez,Alain Colige,Jean-Marie Rakic,Agnès Noël,Joseph Martial,Ingrid Struman +10 more
TL;DR: The results identify miR-21 as a new angiogenesis inhibitor and suggest that inhibition of cell migration and tubulogenesis is mediated through repression of RhoB.
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MMP-2 and MMP-9 synergize in promoting choroidal neovascularization
Vincent Lambert,Ben Wielockx,Carine Munaut,Catherine Galopin,Maud Jost,Takeshi Itoh,Zena Werb,Andrew J. Baker,Claude Libert,Hans-Willi Krell,Jean-Michel Foidart,Agnès Noël,Jean-Marie Rakic +12 more
TL;DR: MMP‐2 and MMP‐9 may cooperate in the development of AMD and that their selective inhibition represents an alternative strategy for the treatment of choroidal neovascularization is suggested.