G
Gert Storm
Researcher at Utrecht University
Publications - 546
Citations - 36914
Gert Storm is an academic researcher from Utrecht University. The author has contributed to research in topics: Liposome & Drug delivery. The author has an hindex of 96, co-authored 530 publications receiving 32703 citations. Previous affiliations of Gert Storm include National University of Singapore & University of Groningen.
Papers
More filters
Journal ArticleDOI
Shielding the cationic charge of nanoparticle-formulated dermal DNA vaccines is essential for antigen expression and immunogenicity.
Joost H. van den Berg,Koen Oosterhuis,Wim E. Hennink,Gert Storm,Leonardus J. van der Aa,Johan F.J. Engbersen,John B. A. G. Haanen,Jos H. Beijnen,Ton N. Schumacher,Bastiaan Nuijen +9 more
TL;DR: It is demonstrated that formulation of DNA into both liposomal and polymeric cationic nanoparticles completely blocks vaccination-induced antigen expression in mice and ex vivo human skin, suggesting that charge shielding forms a generally applicable strategy for the development of dermally applied vaccine formulations.
Journal ArticleDOI
Liposomes for scintigraphic detection of infection and inflammation.
TL;DR: A study in patients suspected of having infectious or inflammatory disease has been initiated and preliminary clinically results exemplify the potential of Tc-99m-PEG liposomes to image infection and inflammation.
Journal ArticleDOI
Pharmacokinetics of poly(hydroxyethyl-L-asparagine)-coated liposomes is superior over that of PEG-coated liposomes at low lipid dose and upon repeated administration
TL;DR: The use of PHEA-liposomes appears beneficial when single low lipid doses and/or repeated dosing schedules are being applied, and the mechanisms behind these observations are still not clear.
Journal ArticleDOI
Gold nanocrystal labeling allows low-density lipoprotein imaging from the subcellular to macroscopic level.
Iris E. Allijn,Wei Leong,Jun Tang,Anita Gianella,Aneta J. Mieszawska,Francois Fay,Ge Ma,Stewart Russell,Catherine B Callo,Ronald E. Gordon,Emine Korkmaz,Jan A. Post,Yiming Zhao,Hans C. Gerritsen,Axel Thran,Roland Proksa,Heiner Daerr,Gert Storm,Valentin Fuster,Edward A. Fisher,Zahi A. Fayad,Willem J. M. Mulder,David P. Cormode +22 more
TL;DR: This work has developed an approach to efficiently load LDL with a range of diagnostically active nanocrystals or hydrophobic agents and should permit the study of lipoprotein biointeractions in unprecedented detail.
Journal ArticleDOI
In vitro cellular handling and in vivo targeting of E-selectin-directed immunoconjugates and immunoliposomes used for drug delivery to inflamed endothelium.
Maaike Everts,Gerben A. Koning,Robbert J. Kok,Sigridur A. Ásgeirsdóttir,Dietmar Vestweber,Dirk K. F. Meijer,Gert Storm,Grietje Molema +7 more
TL;DR: Study on therapeutic effects and side effects in models of chronic inflammation are now necessary to establish pharmacodynamics of dexa-AbEsel and/or AbEsel-immunoliposomes in the treatment of chronicinflammation.