G
Gert Storm
Researcher at Utrecht University
Publications - 546
Citations - 36914
Gert Storm is an academic researcher from Utrecht University. The author has contributed to research in topics: Liposome & Drug delivery. The author has an hindex of 96, co-authored 530 publications receiving 32703 citations. Previous affiliations of Gert Storm include National University of Singapore & University of Groningen.
Papers
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Journal ArticleDOI
MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle
Willem J. M. Mulder,Gustav J. Strijkers,Jo W. Habets,Egbert J. W. Bleeker,Daisy W. J. van der Schaft,Gert Storm,Gerben A. Koning,Arjan W. Griffioen,Klaas Nicolay +8 more
TL;DR: This study demonstrates that MR molecular imaging of angiogenesis is feasible by using a targeted contrast agent specific for the αvβ3‐integrin, and that the multimodality imaging approach gave insight into the exact mechanism of accumulation in the tumor.
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Passive versus active tumor targeting using RGD- and NGR-modified polymeric nanomedicines
Sijumon Kunjachan,Robert Pola,Felix Gremse,Benjamin Theek,Josef Ehling,Diana Moeckel,Benita Hermanns-Sachweh,Michal Pechar,Karel Ulbrich,Wim E. Hennink,Gert Storm,Gert Storm,Wiltrud Lederle,Fabian Kiessling,Twan Lammers,Twan Lammers,Twan Lammers +16 more
TL;DR: It was found that vascular targeting did work, resulting in rapid and efficient early binding to tumor blood vessels, but that over time, passive targeting was significantly more efficient, leading to higher overall levels and to more efficient retention within tumors.
Journal Article
Factors Affecting the Accelerated Blood Clearance of Polyethylene Glycol-Liposomes upon Repeated Injection
Peter Laverman,Myrra G. Carstens,O.C. Boerman,E.Th.M. Dams,Wim J.G. Oyen,N. van Rooijen,F.H.M. Corstens,Gert Storm +7 more
TL;DR: The results indicate that hepatosplenic macrophages play an essential role in the enhanced clearance effect and that the change in pharmacokinetic behavior upon repeated injection is a general characteristic of liposomes, unrelated to the presence of PEG.
Journal ArticleDOI
The battle of “nano” paclitaxel
TL;DR: A comprehensive analysis of these new formulations of PTX demonstrates that they are largely clinically equivalent to Abraxane, indicating significant room for development of a superior nano‐formulation of paclitaxel.
Journal ArticleDOI
Liposomes: quo vadis?
Gert Storm,Daan J.A. Crommelin +1 more
TL;DR: Liposomes have matured as a delivery system for therapeutic agents, and the authors provide their perspective on where the field is going and where opportunities can be found for rational improvement of drug therapy with liposomes.