Gert Storm

TL;DR: This study demonstrates that liposomes surface-modified with HPMA mono/dilactate copolymer are attractive systems for achieving temperature-triggered contents release.

TL;DR: It is reported that the polymersomes functionalized with a Tf-binding peptide CGGGHKYLRW (TBPPs) can selectively and stably bind Tf and subsequently mediate targeted doxorubicin (Dox) delivery to TfR over-expressing HCT-116 colorectal cancer cells in vitro and in vivo.

TL;DR: A novel strategy to reduce fibrotic barrier and enhance efficacy of chemotherapy in pancreatic cancer by using peptidomimetic AV3 against ITGA5, which showed a strong reduction of desmoplasia, leading to decompression of blood vasculature, enhanced tumor perfusion, and thereby the efficacy of gemcitabine in co-injection and patient-derived xenograft tumor models.

TL;DR: Phage display in an in situ brain perfusion model indicates that two new peptide ligands have been identified that may be used for specific targeting of drugs to the blood-brain barrier.

TL;DR: The results indicate that the in vivo behavior of PEG liposomes can be modulated to optimize their characteristics for infection imaging in a rat model.