Gert Storm

TL;DR: The specific combination of tumor model, drug delivery system and drug potency are crucial factors that should be considered in the development and evaluation of new nanomedicines for cancer-inflammation therapy, especially when translating from preclinical models.

TL;DR: In this paper, the authors describe the preparation and optimization of biotin-polyethyleneglycol (PEG) liposomes and their application in experimental infection models to improve the scintigraphic imaging of infection and inflammation.

TL;DR: The results show that Mamu‐DR3 molecules on PBMC can be efficiently loaded in vivo with the above‐mentioned peptides when they are intravenously injected encapsulated in liposomes, but not in the free form.

TL;DR: Investigation of the impact of DDS size on brain accumulation, extravasation and penetration across the blood-brain barrier showed that sonopermeation promoted the accumulation of nanocarriers in mouse brains, and that 10 nm-sized polymeric DDS accumulated more strongly and penetrated deeper into the brain than 100 nm- sized liposomes.

TL;DR: In this paper, the authors investigated the phenotype and function of human CD169+ monocytes in different diseases, their capacity to activate CD8+ T cells, and the potential for a targeted-vaccination approach.