Gert Storm

TL;DR: Noninvasive imaging can be employed to visualize and quantify how efficient passive or active drug targeting is in individual patients and, on this basis, to preselect patients likely to respond to nanomedicine-based chemotherapeutic interventions.

TL;DR: Nanotheranostic systems are considered to be highly suitable systems for (pre-) clinical implementation, not only because they might assist in better understanding various important aspects of the drug delivery process, and in developing better drug delivery systems, but also because they Might contribute to realizing the potential of "personalized medicine", and to developing more effective and less toxic treatment regimens for individual patients.

TL;DR: Recommendations for ligand-targeted PNM approaches include the delivery of drugs that are unable or inefficient in passing cellular membranes, treatment of drug resistant tumors, targeting of the tumor blood supply, the generation of targeted vaccines and nanomedicines that are able to cross the blood-brain barrier.

TL;DR: In this article, the results of a systematic study on liposome variables potentially affecting lymphatic disposition and biodistribution of liposomes after sc injection were reported, showing that the lymphatic uptake from the s.c. injection site of small liposoms (about 0.04 microm) was relatively high (76% of the injected dose (%ID)) as compared to large, non-sized liposOME, which remained almost completely at the site of injection.

TL;DR: It is shown that phagocytosis by macrophages is the most important mechanism for lymph node uptake of liposomes and this has stimulated research on lymphatic targeting ofliposomes for diagnostic and therapeutic applications.