G
Geurt Stokman
Researcher at University of Amsterdam
Publications - 27
Citations - 1465
Geurt Stokman is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Kidney & Reperfusion injury. The author has an hindex of 16, co-authored 22 publications receiving 1321 citations. Previous affiliations of Geurt Stokman include Radboud University Nijmegen & Leiden University.
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Journal ArticleDOI
Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney
Jaklien C. Leemans,Geurt Stokman,Nike Claessen,Kasper M.A. Rouschop,Gwendoline J. D. Teske,Carsten J. Kirschning,Shizuo Akira,Tom van der Poll,Jan J. Weening,Sandrine Florquin +9 more
TL;DR: Analysis of chimeric mice suggested that TLR2 expressed on renal parenchyma plays a crucial role in the induction of inflammation and injury, implying thatTLR2 blockade could provide a basis for therapeutic strategies to treat or prevent renal ischemic injury.
Journal ArticleDOI
Nicotine protects kidney from renal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway.
Claude Sadis,Gwen J. Teske,Geurt Stokman,Carole Kubjak,Nike Claessen,Fabrice Moore,Patrizia Loi,Bilo Diallo,Luc Barvais,Michel Goldman,Sandrine Florquin,Alain Le Moine +11 more
TL;DR: It is highlighted that nicotine exerts a protective anti-inflammatory effect during kidney I/R through the cholinergic α7nAChR pathway, which could provide an opportunity to overcome the effect of surgicalCholinergic denervation during kidney transplantation.
Journal ArticleDOI
Bile acids trigger cholemic nephropathy in common bile‐duct–ligated mice
Peter Fickert,Elisabeth Krones,Marion J. Pollheimer,Andrea Thueringer,Tarek Moustafa,Dagmar Silbert,Emina Halilbasic,Min Yang,Hartmut Jaeschke,Geurt Stokman,Rebecca G. Wells,Kathrin Eller,Alexander R. Rosenkranz,Gösta Eggertsen,Carsten A. Wagner,Cord Langner,Helmut Denk,Michael Trauner +17 more
TL;DR: It is suggested that urinary‐excreted toxic BAs represent a pivotal trigger for renal tubular epithelial injury leading to cholemic nephropathy in CBDL mice, which offers new perspectives to study the complex pathophysiology of this condition.
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Depletion of Gut Microbiota Protects against Renal Ischemia-Reperfusion Injury
Diba Emal,Elena Rampanelli,Ingrid Stroo,Loes M. Butter,Gwendoline J. D. Teske,Nike Claessen,Geurt Stokman,Sandrine Florquin,Sandrine Florquin,Jaklien C. Leemans,Mark C. Dessing +10 more
TL;DR: It is shown that depletion of gut microbiota profoundly protects against renal ischemia-reperfusion (I/R) injury by reducing maturation status of F4/80+ renal resident macrophages and BM monocytes and dampening the inflammatory response by targeting microbiota-derived mediators might be a promising therapy against I/R injury.
Journal ArticleDOI
NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity.
Geurt Stokman,Lotte Kors,Pieter J. Bakker,Elena Rampanelli,Nike Claessen,Gwendoline J. D. Teske,Loes M. Butter,Harmen van Andel,Marius A. van den Bergh Weerman,Per W. B. Larsen,Mark C. Dessing,Coert J. Zuurbier,Stephen E. Girardin,Sandrine Florquin,Jaklien C. Leemans +14 more
TL;DR: Using a chimeric mouse model for renal ischemia-reperfusion injury, it is found that NLRX1 protects against mortality, mitochondrial damage, and epithelial cell apoptosis in an oxidative stress–dependent fashion.