Journal ArticleDOI
p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers.
Monica Hollstein,Marie-Jeanne Marion,Teresa A. Lehman,Judith A. Welsh,Chris Harris,Ghyslaine Martel-Planche,I. Kusters,Ruggero Montesano +7 more
TLDR
In this article, the p53 mutations in cancers of factory workers with a history of carcinogen exposure in the workplace were found in exons 5-8 of the MDM2 gene.Abstract:
Mutations in the p53 tumor suppressor gene are commonly found in the major human cancers and the mutational spectrum in some cancer types is consistent with the genotoxic effects of the associated environmental risk factors. Thus far there is little information on p53 mutations in cancers of factory workers with a history of carcinogen exposure in the workplace. Occupational exposure to vinyl chloride causes liver angiosarcomas (ASL) and also increases the risk of several other cancers. Loss of p53 function in osteo- and fibrosarcomas can occur by two different mechanisms, p53 mutation and amplification of the MDM2 gene. We examined tumors from five vinyl chloride-exposed patients, four with ASL and one with hepatocellular carcinoma (HCC), for evidence of MDM2 proto-oncogene amplification or p53 mutation in exons 5-8. Amplification of MDM2 was not found, but in two of the angiosarcomas an A:T to T:A missense mutation was detected. p53 sequence analysis of vinyl chloride associated cancers may provide valuable information on the relationship between carcinogen exposure and DNA damage in cancer-related genes.read more
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Pathology and genetics of tumors of soft tissue and bone
TL;DR: This list includes tumours of undefined neoplastic nature, which are of uncertain differentiation Bone Tumours, Ewing sarcoma/Primitive neuroedtodermal tumour, Myogenic, lipogenic, neural and epithelial tumours, and others.
Journal ArticleDOI
Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma
Nishant Agrawal,Yuchen Jiao,Chetan Bettegowda,Susan Hutfless,Yuxuan Wang,Stefan David,Yulan Cheng,William S. Twaddell,Nyan L. Latt,Eun Ji Shin,Li-Dong Wang,Liang Wang,Wancai Yang,Victor E. Velculescu,Bert Vogelstein,Nickolas Papadopoulos,Kenneth W. Kinzler,Stephen J. Meltzer +17 more
TL;DR: Exomic sequencing on esophageal adenocarcinomas and ESCCs from the United States highlights key genetic differences and suggests that NOTCH1 is a tumor suppressor gene in the esophagus, and provides a genetic basis for the evolution of EACs from BarrettEsophagus.
Journal ArticleDOI
Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis, Epidemiology, and Risk Assessment
James A. Swenberg,Kun Lu,Benjamin C. Moeller,Lina Gao,Patricia B. Upton,Jun Nakamura,Thomas B. Starr +6 more
TL;DR: 30 years of research on three "known human carcinogens": formaldehyde, vinyl chloride (VC), and ethylene oxide (EO) are utilizes, which outlines quantitative data on endogenous adducts, mutagenicity, and relationships between endogenous and exogenousAdducts.