Gideon Koren

TL;DR: This study supports the continued recommendation to initiate breastfeeding while taking benzodiazepines postpartum and indicates that mothers reporting adverse outcomes in themselves were more likely to be taking concomitantly a greater number of central nervous system depressants.

TL;DR: Fatal opioid toxicity occurred in a developmentally delayed child aged 5 years 9 months who was inadvertently administered high doses of hydrocodone for a respiratory tract infection, and genetic analysis revealed that the child had a reduced capability to metabolize the drug via the CYP2D6 pathway.

TL;DR: Patients' compliance with an orally available chelating agent, 1,2,-dimethyl-3-hydroxypyrid-4-one (L1), that has been demonstrated to induce in vivo iron excretion equivalent to that of desferrioxamine during supervised short term administration, was examined.

TL;DR: A systematic review and meta-analysis of all randomized and cohort studies that reported on the perinatal complications among women with gestational diabetes who received glyburide versus insulin found the drug was not associated with risk of macrosomia, birthweight, gestational age, neonatal hypoglycemia, and intensive care unit (ICU) admissions.

TL;DR: The mechanisms involved in nephrotoxicity include the use of deoxycholate, the vehicle for amphotericin, reduction in renal blood flow and glomerular filtration rate, increased salt concentrations at the macula densa, and apoptosis in proximal tubular cells and medullary interstitial cells.