C
Caroline Lagacé
Researcher at Montreal Heart Institute
Publications - 8
Citations - 3224
Caroline Lagacé is an academic researcher from Montreal Heart Institute. The author has contributed to research in topics: Genome-wide association study & Inflammatory bowel disease. The author has an hindex of 7, co-authored 8 publications receiving 2986 citations. Previous affiliations of Caroline Lagacé include Université de Montréal.
Papers
More filters
Journal ArticleDOI
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Carl A. Anderson,Gabrielle Boucher,Charlie W. Lees,Andre Franke,Mauro D'Amato,Kent D. Taylor,James Lee,Philippe Goyette,Marcin Imielinski,Anna Latiano,Caroline Lagacé,Regan Scott,Leila Amininejad,Suzannah Bumpstead,Leonard Baidoo,Robert N. Baldassano,Murray L. Barclay,Theodore M. Bayless,Stephan Brand,Carsten Büning,Jean-Frederic Colombel,Lee A. Denson,Martine De Vos,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Rudolf S N Fehrmann,James A B Floyd,Timothy H. Florin,Denis Franchimont,Lude Franke,Michel Georges,Jürgen Glas,Nicole L. Glazer,Stephen L. Guthery,Talin Haritunians,Nicholas K. Hayward,Jean-Pierre Hugot,Gilles Jobin,Debby Laukens,Ian C. Lawrance,Marc Lémann,Arie Levine,Cécile Libioulle,Edouard Louis,Dermot P.B. McGovern,Monica Milla,Grant W. Montgomery,Katherine I. Morley,Craig Mowat,Aylwin Ng,William G. Newman,Roel A. Ophoff,Laura Papi,Orazio Palmieri,Laurent Peyrin-Biroulet,Julián Panés,Anne M. Phillips,Natalie J. Prescott,Deborah D. Proctor,Rebecca L. Roberts,Richard K Russell,Paul Rutgeerts,Jeremy D. Sanderson,Miquel Sans,Philip Schumm,Frank Seibold,Yashoda Sharma,Lisa A. Simms,Mark Seielstad,Mark Seielstad,A. Hillary Steinhart,Stephan R. Targan,Leonard H. van den Berg,Morten H. Vatn,Hein W. Verspaget,Thomas D. Walters,Cisca Wijmenga,David C. Wilson,Harm-Jan Westra,Ramnik J. Xavier,Zhen Zhen Zhao,Cyriel Y. Ponsioen,Vibeke Andersen,Leif Törkvist,Maria Gazouli,Nicholas P. Anagnou,Tom H. Karlsen,Limas Kupčinskas,Jurgita Sventoraityte,John C. Mansfield,Subra Kugathasan,Mark S. Silverberg,Jonas Halfvarson,Jerome I. Rotter,Christopher G. Mathew,Anne M. Griffiths,Richard B. Gearry,Tariq Ahmad,Steven R. Brant,Mathias Chamaillard,Jack Satsangi,Judy H. Cho,Stefan Schreiber,Mark J. Daly,Jeffrey C. Barrett,Miles Parkes,Vito Annese,Hakon Hakonarson,Graham L. Radford-Smith,Richard H. Duerr,Severine Vermeire,Rinse K. Weersma,John D. Rioux +113 more
TL;DR: A meta-analysis of six ulcerative colitis genome-wide association study datasets found many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1.
Journal ArticleDOI
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Manuel A. Rivas,Manuel A. Rivas,Manuel A. Rivas,Mélissa Beaudoin,Agnes Gardet,Christine Stevens,Yashoda Sharma,Clarence K. Zhang,Gabrielle Boucher,Stephan Ripke,Stephan Ripke,David Ellinghaus,Noël P. Burtt,Timothy Fennell,Andrew Kirby,Andrew Kirby,Anna Latiano,Philippe Goyette,Todd Green,Jonas Halfvarson,Talin Haritunians,Joshua M. Korn,Finny G Kuruvilla,Caroline Lagacé,Benjamin M. Neale,Benjamin M. Neale,Ken Sin Lo,Phil Schumm,Leif Törkvist,Marla Dubinsky,Steven R. Brant,Mark S. Silverberg,Richard H. Duerr,David Altshuler,David Altshuler,Stacey Gabriel,Guillaume Lettre,Andre Franke,Mauro D'Amato,Dermot P.B. McGovern,Judy H. Cho,John D. Rioux,Ramnik J. Xavier,Ramnik J. Xavier,Mark J. Daly,Mark J. Daly +45 more
TL;DR: Next-generation sequencing is used to study 56 genes from regions associated with Crohn's disease in 350 cases and 350 controls to identify new, rare and probably functional variants that could aid functional experiments and predictive models.
Journal ArticleDOI
Genome-wide association identifies multiple ulcerative colitis susceptibility loci
Dermot P.B. McGovern,Agnes Gardet,Leif Törkvist,Philippe Goyette,Jonah Essers,Kent D. Taylor,Benjamin M. Neale,Rick Twee-Hee Ong,Caroline Lagacé,Chun Li,Todd Green,Christine Stevens,Claudine Beauchamp,Phillip Fleshner,Marie Carlson,Mauro D'Amato,Jonas Halfvarson,Martin L. Hibberd,Mikael Lördal,Leonid Padyukov,Angelo Andriulli,Elisabetta Colombo,Anna Latiano,Orazio Palmieri,Edmond Jean Bernard,Colette Deslandres,Daan W. Hommes,Dirk J. de Jong,Pieter C. F. Stokkers,Rinse K. Weersma,Yashoda Sharma,Mark S. Silverberg,Judy H. Cho,Jing Wu,Jing Wu,Kathryn Roeder,Steven R. Brant,L Phillip Schumm,Richard H. Duerr,Marla Dubinsky,Nicole L. Glazer,Talin Haritunians,Andrew Ippoliti,Gil Y. Melmed,David S. Siscovick,Eric A. Vasiliauskas,Stephan R. Targan,Vito Annese,Cisca Wijmenga,Sven Pettersson,Jerome I. Rotter,Jerome I. Rotter,Ramnik J. Xavier,Mark J. Daly,John D. Rioux,Mark Seielstad +55 more
TL;DR: Two distinct genome-wide association studies of ulcerative colitis are presented and their joint analysis with a previously published scan shows that roughly half of the known Crohn's disease associations are shared with ulceratives colitis, thereby providing insight into disease pathogenesis.
Journal ArticleDOI
A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease
Eleonora A. M. Festen,Philippe Goyette,Todd Green,Gabrielle Boucher,Claudine Beauchamp,Gosia Trynka,Patrick Dubois,Caroline Lagacé,Pieter C. F. Stokkers,Daan W. Hommes,Donatella Barisani,Orazio Palmieri,Vito Annese,David A. van Heel,Rinse K. Weersma,Mark J. Daly,Mark J. Daly,Cisca Wijmenga,John D. Rioux +18 more
TL;DR: The combined analysis of the two datasets provided the power, lacking in the individual GWAS for single diseases, to detect shared loci with a relatively small effect and identified four shared risk loci: PTPN2, IL18RAP, TAGAP, and PUS10.
Journal ArticleDOI
Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis
Mélissa Beaudoin,Philippe Goyette,Gabrielle Boucher,Ken Sin Lo,Manuel A. Rivas,Christine Stevens,Azadeh Alikashani,Martin Ladouceur,David Ellinghaus,Leif Törkvist,Gautam Goel,Caroline Lagacé,Vito Annese,Alain Bitton,Jakob Begun,S Brant,Francesca Bresso,Judy H. Cho,Richard H. Duerr,Jonas Halfvarson,Dermot P.B. McGovern,Graham L. Radford-Smith,Stefan Schreiber,Philip Schumm,Yashoda Sharma,Mark S. Silverberg,Rinse K. Weersma,Mauro D'Amato,Severine Vermeire,Andre Franke,Guillaume Lettre,Guillaume Lettre,Ramnik J. Xavier,Ramnik J. Xavier,Mark J. Daly,John D. Rioux,John D. Rioux +36 more
TL;DR: It is suggested that rare variants in genes identified by genome-wide association in UC are unlikely to contribute significantly to the overall variance for the disease, and are expected to help focus functional studies of the corresponding disease loci.