Simona Boncompagni

TL;DR: A significant reduction of the regenerative potential of muscle fibres is due to a reduced pool of satellite cells that are usually recruited to replace damaged fibres and promote their regeneration.

TL;DR: A feed-forward cyclic mechanism is proposed that increases the temperature sensitivity of RyR1 activation and underlies heat stroke and sudden death, and eventually produces a myopathy with damaged mitochondria.

TL;DR: It is shown that genetic ablation of the pro-fission protein DRP1 leads to accumulation of abnormal mitochondria that induce muscle atrophy by altering Ca2+ homeostasis and cellular stress responses.

TL;DR: T tethers are suggested to establish and maintain SR-mitochondrial association during postnatal maturation and in adult muscle and likely provide a structural framework for bi-directional signaling between the two organelles in striated muscle.

TL;DR: Regular physical activity is a good strategy to attenuate age-related general decay of muscle structure and function and signaling pathways controlling muscle mass and metabolism are differently modulated in senior sportsmen to guarantee maintenance of skeletal muscle structure, function, bioenergetic characteristics and phenotype.