G
Graham F. Barnard
Researcher at University of Massachusetts Medical School
Publications - 54
Citations - 3643
Graham F. Barnard is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Cancer & Gene expression. The author has an hindex of 26, co-authored 54 publications receiving 3506 citations. Previous affiliations of Graham F. Barnard include UMass Memorial Health Care & University of Massachusetts Amherst.
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Journal ArticleDOI
Characterization of a side population of cancer cells from human gastrointestinal system
Naotsugu Haraguchi,Tohru Utsunomiya,Hiroshi Inoue,Fumiaki Tanaka,Koshi Mimori,Graham F. Barnard,Masaki Mori +6 more
TL;DR: It is demonstrated that cancers of the gastrointestinal system do contain SP cells that show some characteristics of so‐called stem cells.
Journal ArticleDOI
CD13 is a therapeutic target in human liver cancer stem cells
Naotsugu Haraguchi,Hideshi Ishii,Hideshi Ishii,Koshi Mimori,Fumiaki Tanaka,Masahisa Ohkuma,Ho Min Kim,Hirofumi Akita,Daisuke Takiuchi,Hisanori Hatano,Hiroaki Nagano,Graham F. Barnard,Yuichiro Doki,Masaki Mori +13 more
TL;DR: It is demonstrated that CD13 is a marker for semiquiescent CSCs in human liver cancer cell lines and clinical samples and that targeting these cells might provide a way to treat this disease.
Journal Article
Detection of cancer micrometastases in lymph nodes by reverse transcriptase-polymerase chain reaction
Masaki Mori,Koshi Mimori,Hiroshi Inoue,Graham F. Barnard,Koichi Tsuji,Shigeru Nanbara,Hiroaki Ueo,Tsuyoshi Akiyoshi +7 more
TL;DR: The assay by CEA-specific nested RT-PCR is not only sensitive but widely applicable for the detection of cancer micrometastases in lymph nodes, which may lead to an earlier diagnosis and treatment of patients with subclinical lymph node metastasis.
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Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis
Takehiko Yokobori,Hisae Iinuma,Teppei Shimamura,Seiya Imoto,Keishi Sugimachi,Hideshi Ishii,Masaaki Iwatsuki,Daisuke Ota,Masahisa Ohkuma,Takeshi Iwaya,Naohiro Nishida,Ryunosuke Kogo,Tomoya Sudo,Fumiaki Tanaka,Kohei Shibata,Hiroyuki Toh,Tetsuya Sato,Graham F. Barnard,Takeo Fukagawa,Seiichiro Yamamoto,Hayao Nakanishi,Shin Sasaki,Satoru Miyano,Toshiaki Watanabe,Hiroyuki Kuwano,Koshi Mimori,Klaus Pantel,Masaki Mori +27 more
TL;DR: PLS3-positive CTC was independently associated with prognosis in the training set and the validation set, and it possesses significant prognostic value.
Journal ArticleDOI
Molecular detection of circulating solid carcinoma cells in the peripheral blood: The concept of early systemic disease
Masaki Mori,Koshi Mimori,Hiroaki Ueo,Nobuya Karimine,Graham F. Barnard,Keizo Sugimachi,Tsuyoshi Akiyoshi +6 more
TL;DR: It is suggested that RT‐PCR amplification of CEA mRNA is an efficient means of detecting circulating solid cancer cells in the peripheral blood, although long‐term clinical studies should be done to evaluate its usefulness; not only breast cancer but also gastrointestinal cancer might be better regarded as a systemic disease even in early stages of carcinoma.