H
Hayao Nakanishi
Researcher at Nagoya University
Publications - 169
Citations - 5505
Hayao Nakanishi is an academic researcher from Nagoya University. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 40, co-authored 163 publications receiving 5158 citations.
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Journal ArticleDOI
Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour–stroma interaction
Takaya Nagasaki,Masayasu Hara,Hayao Nakanishi,Hiroki Takahashi,Mikinori Sato,Hiromitsu Takeyama +5 more
TL;DR: It is demonstrated that stromal fibroblasts isolated from colon cancer produced significant amounts of IL-6 and that colon cancer cells enhanced IL- 6 production by stromals, thereby inducing angiogenesis and offering new approaches to cancer therapy.
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Identification of a major carbohydrate capping group of the l-selectin ligand on high endothelial venules in human lymph nodes as 6-sulfo sialyl lewis x
Chikako Mitsuoka,Mikiko Sawada-Kasugai,Keiko Ando-Furui,Mineko Izawa,Hayao Nakanishi,Shigeo Nakamura,Hideharu Ishida,Makoto Kiso,Reiji Kannagi +8 more
TL;DR: The newly generated monoclonal antibodies directed against 6-sulfo sialyl Lewis X, which intensely labeled HEV in immunohistochemical examination and inhibited binding of recombinant L- selectin-IgG to HEV, suggest that the determinant serves as a ligand for L-selectin.
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Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis
Takehiko Yokobori,Hisae Iinuma,Teppei Shimamura,Seiya Imoto,Keishi Sugimachi,Hideshi Ishii,Masaaki Iwatsuki,Daisuke Ota,Masahisa Ohkuma,Takeshi Iwaya,Naohiro Nishida,Ryunosuke Kogo,Tomoya Sudo,Fumiaki Tanaka,Kohei Shibata,Hiroyuki Toh,Tetsuya Sato,Graham F. Barnard,Takeo Fukagawa,Seiichiro Yamamoto,Hayao Nakanishi,Shin Sasaki,Satoru Miyano,Toshiaki Watanabe,Hiroyuki Kuwano,Koshi Mimori,Klaus Pantel,Masaki Mori +27 more
TL;DR: PLS3-positive CTC was independently associated with prognosis in the training set and the validation set, and it possesses significant prognostic value.
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TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth
Makiko Fujii,Takeshi Toyoda,Hayao Nakanishi,Yasushi Yatabe,Ayuko Sato,Yasue Matsudaira,Hidemi Ito,Hideki Murakami,Yutaka Kondo,Eisaku Kondo,Toyoaki Hida,Tohru Tsujimura,Hirotaka Osada,Yoshitaka Sekido +13 more
TL;DR: Hippo and TGF-β converge on CTGF to promote malignant mesothelioma and this results in a “cell reprograming” that down-regulates the number of “bad” cells in the immune system.
Journal Article
Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils.
Nobuyuki Shimizu,Yuzuru Ikehara,Ken Ichi Inada,Hayao Nakanishi,Tetsuya Tsukamoto,Koji Nozaki,Michio Kaminishi,Shu Kuramoto,Atsushi Sugiyama,Tsutomu Katsuyama,Masae Tatematsu +10 more
TL;DR: This study shows that Hp eradication may be useful as a prevention approach against stomach cancer.