H
Hiroaki Nagano
Researcher at Yamaguchi University
Publications - 596
Citations - 18678
Hiroaki Nagano is an academic researcher from Yamaguchi University. The author has contributed to research in topics: Hepatocellular carcinoma & Cancer. The author has an hindex of 62, co-authored 567 publications receiving 15731 citations. Previous affiliations of Hiroaki Nagano include Osaka University & Osaka City University.
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Journal ArticleDOI
International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study
Franck Pagès,Bernhard Mlecnik,Florence Marliot,Gabriela Bindea,Gabriela Bindea,Gabriela Bindea,Fang Shu Ou,Carlo Bifulco,Alessandro Lugli,Inti Zlobec,Tilman T. Rau,Martin D. Berger,Iris D. Nagtegaal,Elisa Vink-Börger,Arndt Hartmann,Carol Geppert,Julie Kolwelter,Susanne Merkel,Robert Grützmann,Marc Van den Eynde,Anne Jouret-Mourin,Alex Kartheuser,Daniel Léonard,Christophe Remue,Julia Y. Wang,Julia Y. Wang,Prashant Bavi,Michael H.A. Roehrl,Michael H.A. Roehrl,Michael H.A. Roehrl,Pamela S. Ohashi,Linh T. Nguyen,Seong Jun Han,Heather L. MacGregor,Sara Hafezi-Bakhtiari,Bradly G. Wouters,Giuseppe Masucci,Emilia Andersson,Eva Zavadova,Michal Vocka,Jan Spacek,Lubos Petruzelka,Bohuslav Konopasek,Pavel Dundr,Helena Skalova,Kristyna Nemejcova,Gerardo Botti,Fabiana Tatangelo,Paolo Delrio,Gennaro Ciliberto,Michele Maio,Luigi Laghi,Fabio Grizzi,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Bénédicte Buttard,Bénédicte Buttard,Bénédicte Buttard,Mihaela Angelova,Mihaela Angelova,Mihaela Angelova,Angela Vasaturo,Angela Vasaturo,Angela Vasaturo,Pauline Maby,Pauline Maby,Pauline Maby,Sarah E. Church,Helen K. Angell,Lucie Lafontaine,Lucie Lafontaine,Lucie Lafontaine,Daniela Bruni,Daniela Bruni,Daniela Bruni,Carine El Sissy,Nacilla Haicheur,Amos Kirilovsky,Anne Berger,Christine Lagorce,Jeffrey P. Meyers,Christopher Paustian,Zipei Feng,Carmen Ballesteros-Merino,Jeroen R. Dijkstra,Carlijn van de Water,Shannon van Vliet,Nikki Knijn,Ana Maria Mușină,Dragos Viorel Scripcariu,Boryana Popivanova,Mingli Xu,Tomonobu Fujita,Shoichi Hazama,Nobuaki Suzuki,Hiroaki Nagano,Kiyotaka Okuno,Toshihiko Torigoe,Noriyuki Sato,Tomohisa Furuhata,Ichiro Takemasa,Kyogo Itoh,P. Patel,Hemangini H. Vora,Birva Shah,Jayendrakumar B. Patel,Kruti N. Rajvik,Shashank J. Pandya,Shilin N. Shukla,Yili Wang,Guanjun Zhang,Yutaka Kawakami,Francesco M. Marincola,Paolo A. Ascierto,Daniel J. Sargent,Bernard A. Fox,Bernard A. Fox,Jérôme Galon,Jérôme Galon,Jérôme Galon +120 more
TL;DR: The immunoscore provides a reliable estimate of the risk of recurrence in patients with colon cancer and supports the implementation of the consensus Immunoscore as a new component of a TNM-Immune classification of cancer.
Journal ArticleDOI
Reprogramming of mouse and human cells to pluripotency using mature microRNAs.
Norikatsu Miyoshi,Hideshi Ishii,Hideshi Ishii,Hiroaki Nagano,Naotsugu Haraguchi,Dyah Laksmi Dewi,Yoshihiro Kano,Shinpei Nishikawa,Masahiro Tanemura,Koshi Mimori,Fumiaki Tanaka,Toshiyuki Saito,Junichi Nishimura,Ichiro Takemasa,Tsunekazu Mizushima,Masataka Ikeda,Hirofumi Yamamoto,Mitsugu Sekimoto,Yuichiro Doki,Masaki Mori,Masaki Mori +20 more
TL;DR: It is shown here that it is possible to reprogram mouse and human cells to pluripotency by direct transfection of mature double-stranded microRNAs (miRNAs) and it holds significant potential for biomedical research and regenerative medicine.
Journal ArticleDOI
CD13 is a therapeutic target in human liver cancer stem cells
Naotsugu Haraguchi,Hideshi Ishii,Hideshi Ishii,Koshi Mimori,Fumiaki Tanaka,Masahisa Ohkuma,Ho Min Kim,Hirofumi Akita,Daisuke Takiuchi,Hisanori Hatano,Hiroaki Nagano,Graham F. Barnard,Yuichiro Doki,Masaki Mori +13 more
TL;DR: It is demonstrated that CD13 is a marker for semiquiescent CSCs in human liver cancer cell lines and clinical samples and that targeting these cells might provide a way to treat this disease.
Journal ArticleDOI
Clinical practice guidelines for hepatocellular carcinoma: The Japan Society of Hepatology 2017 (4th JSH-HCC guidelines) 2019 update.
Norihiro Kokudo,Nobuyuki Takemura,Kiyoshi Hasegawa,Tadatoshi Takayama,Shoji Kubo,Mitsuo Shimada,Hiroaki Nagano,Etsuro Hatano,Namiki Izumi,Shuichi Kaneko,Masatoshi Kudo,Hiroko Iijima,Takuya Genda,Ryosuke Tateishi,Takuji Torimura,Hiroshi Igaki,Satoshi Kobayashi,Hideyuki Sakurai,Takamichi Murakami,Takeyuki Watadani,Yutaka Matsuyama +20 more
TL;DR: The fourth version of Clinical Practice Guidelines for Hepatocellular Carcinoma was revised by the Japan Society of Hepatology, according to the methodology of evidence‐based medicine and partly to the Grading of Recommendations Assessment, Development, and Evaluation system, which was published in October 2017 in Japanese.
Journal ArticleDOI
The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma
Satoshi Shimizu,Tetsuo Takehara,Hayato Hikita,Takahiro Kodama,Takuya Miyagi,Atsushi Hosui,Tomohide Tatsumi,Hisashi Ishida,Takehiro Noda,Hiroaki Nagano,Yuichiro Doki,Masaki Mori,Norio Hayashi +12 more
TL;DR: Let-7 microRNAs negatively regulate Bcl-xL expression in human hepatocellular carcinomas and induce apoptosis in cooperation with an anti-cancer drug targeting Mcl-1.