G
Guanlin Wang
Researcher at University of Oxford
Publications - 36
Citations - 786
Guanlin Wang is an academic researcher from University of Oxford. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 24 publications receiving 393 citations. Previous affiliations of Guanlin Wang include Chinese Academy of Sciences & China Jiliang University.
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Journal ArticleDOI
Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice.
Sumei Hu,Lu Wang,Lu Wang,Deng-Bao Yang,Li Li,Jacques Togo,Yingga Wu,Quansheng Liu,Baoguo Li,Min Li,Guanlin Wang,Guanlin Wang,Xueying Zhang,Xueying Zhang,Chaoqun Niu,Jianbo Li,Yan-Chao Xu,Elspeth Couper,Andrew Whittington-Davies,Mohsen Mazidi,Lijuan Luo,Shengnan Wang,Alex Douglas,John R. Speakman,John R. Speakman,John R. Speakman +25 more
TL;DR: Mice regulate their food consumption primarily to meet an energy rather than a protein target, but this system can be over-ridden by hedonic factors linked to fat, but not sucrose, consumption.
Journal ArticleDOI
Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue
Baoguo Li,Li Li,Min Li,Min Li,Sin Man Lam,Guanlin Wang,Guanlin Wang,Yingga Wu,Yingga Wu,Hanlin Zhang,Chaoqun Niu,Xueying Zhang,Xueying Zhang,Xue liu,Catherine Hambly,Wanzhu Jin,Guanghou Shui,John R. Speakman,John R. Speakman,John R. Speakman +19 more
TL;DR: Gavage of the bacterial metabolite butyrate increased the thermogenic capacity of ABX-treated mice, reversing the deficit and indicating that gut microbiota contributes to upregulated thermogenesis in the cold environment and that this may be partially mediated viabutyrate.
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Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets
Bethan Psaila,Guanlin Wang,Alba Rodriguez-Meira,Rong Li,Elisabeth F. Heuston,Lauren Murphy,Daniel Yee,Ian S. Hitchcock,Nikolaos Sousos,Jennifer O'Sullivan,Stacie M. Anderson,Yotis A. Senis,Olga K. Weinberg,Monica L. Calicchio,Deena Iskander,Daniel Royston,Dragana Milojkovic,Irene Roberts,David M. Bodine,Supat Thongjuea,Adam J. Mead,Adam J. Mead +21 more
TL;DR: This study paves the way for selective targeting of the myelofibrosis clone and illustrates the power of single-cell multi-omics to discover tumor-specific therapeutic targets and mediators of tissue fibrosis.
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Analysis of Positive Selection at Single Nucleotide Polymorphisms Associated with Body Mass Index Does Not Support the “Thrifty Gene” Hypothesis
TL;DR: The widespread absence of signatures of positive selection, combined with selection favoring leanness at some alleles, does not support the suggestion that obesity provided a selective advantage to survive famines, or any other selective advantage.
Journal ArticleDOI
The developing mouse coronal suture at single-cell resolution.
D'Juan T Farmer,Hana Mlcochova,Yan Zhou,Nils Koelling,Guanlin Wang,Neil Ashley,Helena Bugacov,Hung-Jhen Chen,Riana K. Parvez,Kuo-Chang Tseng,Amy E. Merrill,Robert E. Maxson,Andrew O.M. Wilkie,J. Gage Crump,Stephen R.F. Twigg +14 more
TL;DR: This single-cell atlas provides a resource for understanding the development of the coronal suture and the mechanisms for its loss in craniosynostosis.