Gunjan Mandal

TL;DR: It is demonstrated that exosomes secreted by human and mouse tumor-educated mesenchymal stem cells drive accelerated breast cancer progression by inducing differentiation of monocytic myeloid-derived suppressor cells into highly immunosuppressive M2-polarized macrophages at tumor beds.

TL;DR: The EMT-inducing potential of CXCL13 is shown as well as the prognostic value of C XCL13–CXCR5 co-expression in primary BC is demonstrated, suggesting that CxCL13-CX CR5–RANKL–Src axis may present a therapeutic target in LNM positive BC patients.

TL;DR: In this article, the authors show that robust, protective humoral responses are dominated by the production of polyclonal IgA, which binds to polymeric IgA receptors that are universally expressed on ovarian cancer cells.

TL;DR: The butyrophilin BTN3A1 inhibits tumor-reactive αβ T cell receptor activation by preventing segregation of N-glycosylated CD45 from the immune synapse and may present a treatment strategy for tumors resistant to existing immunotherapies.

TL;DR: MiR-222/LBR have key roles in controlling pro-progression influences of CAFs in BC and this pathway may present therapeutic opportunities to inhibit CAF-induced cancer progression.