G
Guoying Dong
Researcher at Nanjing Medical University
Publications - 5
Citations - 1025
Guoying Dong is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Gene targeting & Offspring. The author has an hindex of 4, co-authored 5 publications receiving 916 citations.
Papers
More filters
Journal ArticleDOI
Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
Yuyu Niu,Bin Shen,Yiqiang Cui,Yongchang Chen,Jianying Wang,Lei Wang,Yu Kang,Xiaoyang Zhao,Wei Si,Wei Li,Andy Peng Xiang,Jiankui Zhou,Xuejiang Guo,Ye Bi,Chenyang Si,Bian Hu,Guoying Dong,Hong Wang,Zuomin Zhou,Tianqing Li,Tao Tan,Xiuqiong Pu,Fang Wang,Shaohui Ji,Qi Zhou,Xingxu Huang,Weizhi Ji,Jiahao Sha +27 more
TL;DR: By coinjection of Cas9 mRNA and sgRNAs into one-cell-stage embryos, this system successfully achieves precise gene targeting in cynomolgus monkeys and enables simultaneous disruption of two target genes in one step, and no off-target mutagenesis was detected by comprehensive analysis.
Journal ArticleDOI
Blastomere biopsy influences epigenetic reprogramming during early embryo development, which impacts neural development and function in resulting mice.
Yibo Wu,Zhuo Lv,Yang Yang,Guoying Dong,Yang Yu,Yiqiang Cui,Man Tong,Liu Wang,Zuomin Zhou,Hui Zhu,Qi Zhou,Jiahao Sha +11 more
TL;DR: It is found that aged biopsied mice had poorer spatial learning ability, increased neuron degeneration, and altered expression of proteins involved in neural degeneration or dysfunction in the brain compared to aged control mice, demonstrating an abnormal neural development and function in mice generated after blastomere biopsy.
Journal ArticleDOI
Long-term effects of repeated superovulation on ovarian structure and function in rhesus monkeys
TL;DR: It is indicated that repeated COH could change the expression of many proteins in the ovaries even after several years, potentially affecting the development and function of ovarian cells.
Journal ArticleDOI
A potential high risk for fatty liver disease was found in mice generated after assisted reproductive techniques.
Leilei Gu,Jingjing Zhang,Meimei Zheng,Guoying Dong,Jingyi Xu,Wuyue Zhang,Yibo Wu,Yang Yang,Hui Zhu +8 more
TL;DR: It is demonstrated that ARTs procedures have adverse effect on liver development which resulted in abnormal lipid metabolism and induced the potential high risk of fatty liver in adulthood.
Journal ArticleDOI
Long-term effects of repeated superovulation on the uterus and mammary gland in rhesus monkeys.
TL;DR: Repeated COH affects the expression of the uterine development-related gene several years later, and uterine cells exhibited a low proliferation status.