H
Haiqing Shen
Researcher at University of Maryland, Baltimore
Publications - 48
Citations - 6597
Haiqing Shen is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 31, co-authored 48 publications receiving 6228 citations. Previous affiliations of Haiqing Shen include University of Maryland, Baltimore County & United States Department of Agriculture.
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Journal ArticleDOI
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
Cristen J. Willer,Serena Sanna,Anne U. Jackson,Angelo Scuteri,Lori L. Bonnycastle,Robert Clarke,Simon Heath,Nicholas J. Timpson,Samer S. Najjar,Heather M. Stringham,James B. Strait,William L. Duren,Andrea Maschio,Fabio Busonero,Antonella Mulas,Giuseppe Albai,Amy J. Swift,Mario A. Morken,Narisu Narisu,Derrick A Bennett,Sarah Parish,Haiqing Shen,Pilar Galan,Pierre Meneton,Serge Hercberg,Diana Zelenika,Wei-Min Chen,Yun Li,Laura J. Scott,Paul Scheet,Jouko Sundvall,Richard M. Watanabe,Ramaiah Nagaraja,Shah Ebrahim,Debbie A Lawlor,Yoav Ben-Shlomo,George Davey-Smith,Alan R. Shuldiner,Rory Collins,Richard N. Bergman,Manuela Uda,Jaakko Tuomilehto,Jaakko Tuomilehto,Antonio Cao,Francis S. Collins,Edward G. Lakatta,G. Mark Lathrop,Michael Boehnke,David Schlessinger,Karen L. Mohlke,Gonçalo R. Abecasis +50 more
TL;DR: In this paper, the authors used genotype imputation and meta-analysis to identify genetic variants influencing plasma lipid concentrations, using three genome-wide scans totaling 8,816 individuals and comprising 6,068 individuals specific to their study.
Journal ArticleDOI
A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
Toni I. Pollin,Coleen M. Damcott,Haiqing Shen,Sandra Ott,John Shelton,Richard B. Horenstein,Wendy S. Post,John C. McLenithan,John C. McLenithan,Lawrence F. Bielak,Patricia A. Peyser,Braxton D. Mitchell,Michael Miller,Jeffrey R. O'Connell,Alan R. Shuldiner,Alan R. Shuldiner +15 more
TL;DR: Mutation carriers compared with noncarriers had lower fasting and postprandial serum triglycerides, higher levels of HDL-ch cholesterol and lower levels of LDL-cholesterol, which suggests that lifelong deficiency of apoC-III has a cardioprotective effect.
Journal ArticleDOI
Common variants in the GDF5-UQCC region are associated with variation in human height
Serena Sanna,Anne U. Jackson,Ramaiah Nagaraja,Cristen J. Willer,Wei-Min Chen,Wei-Min Chen,Lori L. Bonnycastle,Haiqing Shen,Nicholas J. Timpson,Guillaume Lettre,Gianluca Usala,Peter S. Chines,Heather M. Stringham,Laura J. Scott,Mariano Dei,Sandra Lai,Giuseppe Albai,Laura Crisponi,Silvia Naitza,Kimberly F. Doheny,Elizabeth W. Pugh,Yoav Ben-Shlomo,Shah Ebrahim,Debbie A Lawlor,Richard N. Bergman,Richard M. Watanabe,Manuela Uda,Jaakko Tuomilehto,Jaakko Tuomilehto,Josef Coresh,Joel N. Hirschhorn,Alan R. Shuldiner,Alan R. Shuldiner,David Schlessinger,Francis S. Collins,George Davey Smith,Eric Boerwinkle,Antonio Cao,Michael Boehnke,Gonçalo R. Abecasis,Karen L. Mohlke +40 more
TL;DR: It is shown that common variants in the osteoarthritis-associated locus GDF5-UQCC contribute to variation in height with an estimated additive effect of 0.44 cm (overall P < 10−15).
Journal ArticleDOI
Whole-genome association study identifies STK39 as a hypertension susceptibility gene
Ying Wang,Jeffrey R. O'Connell,Patrick F. McArdle,James B. Wade,Sarah E. Dorff,Sanjiv J. Shah,Xiaolian Shi,Lin Pan,Evadnie Rampersaud,Haiqing Shen,James Kim,Arohan R. Subramanya,Nanette I. Steinle,Afshin Parsa,Carole Ober,Paul A. Welling,Aravinda Chakravarti,Alan B. Weder,Richard S. Cooper,Braxton D. Mitchell,Alan R. Shuldiner,Yen Pei C. Chang +21 more
TL;DR: A genome-wide association study of systolic and diastolic blood pressure in Amish subjects and found strong association signals with common variants in a serine/threonine kinase gene, STK39, thus unifying rare and common BP-regulating alleles in the same physiological pathway.
Journal ArticleDOI
Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.
Coleen M. Damcott,Toni I. Pollin,Laurie J. Reinhart,Sandra Ott,Haiqing Shen,Kristi D. Silver,Braxton D. Mitchell,Alan R. Shuldiner,Alan R. Shuldiner +8 more
TL;DR: Replicating evidence that variants in TCF7L2 increase the risk for type 2 diabetes and novel evidence that the variants likely influence both insulin secretion and insulin sensitivity are provided.