R
Richard B. Horenstein
Researcher at University of Maryland, Baltimore
Publications - 43
Citations - 5242
Richard B. Horenstein is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Clopidogrel & Platelet aggregation inhibitor. The author has an hindex of 26, co-authored 43 publications receiving 4750 citations. Previous affiliations of Richard B. Horenstein include Johns Hopkins University & United States Department of Veterans Affairs.
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Journal ArticleDOI
Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy
Alan R. Shuldiner,Jeffrey R. O'Connell,Kevin P. Bliden,Amish Gandhi,Kathleen A. Ryan,Richard B. Horenstein,Coleen M. Damcott,Ruth E. Pakyz,Udaya S. Tantry,Quince Gibson,Toni I. Pollin,Wendy S. Post,Afshin Parsa,Braxton D. Mitchell,Nauder Faraday,William R. Herzog,Paul A. Gurbel +16 more
TL;DR: CYP2C19*2 genotype was associated with diminished platelet response to clopidogrel treatment and poorer cardiovascular outcomes, and patients with the CYP2C 19*2 variant were more likely to have a cardiovascular ischemic event or death during 1 year of follow-up.
Journal ArticleDOI
A Pharmacogenetic versus a Clinical Algorithm for Warfarin Dosing
Stephen E. Kimmel,Benjamin French,Scott E. Kasner,Julie A. Johnson,Jeffrey L. Anderson,Brian F. Gage,Yves Rosenberg,Charles S. Eby,Rosemary Madigan,Robert B. McBane,Sherif Z. Abdel-Rahman,Scott M. Stevens,Steven H. Yale,Emile R. Mohler,Margaret C. Fang,Vinay Shah,Richard B. Horenstein,Nita A. Limdi,James A.S. Muldowney,Jaspal S Gujral,Patrice Delafontaine,Robert J. Desnick,Thomas L. Ortel,Henny H. Billett,Robert C. Pendleton,Nancy L. Geller,Jonathan L. Halperin,Samuel Z. Goldhaber,Michael D. Caldwell,Robert M. Califf,Jonas H. Ellenberg +30 more
TL;DR: Genotype-guided dosing of warfarin did not improve anticoagulation control during the first 4 weeks of therapy and there was a significant interaction between dosing strategy and race.
Journal ArticleDOI
A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
Toni I. Pollin,Coleen M. Damcott,Haiqing Shen,Sandra Ott,John Shelton,Richard B. Horenstein,Wendy S. Post,John C. McLenithan,John C. McLenithan,Lawrence F. Bielak,Patricia A. Peyser,Braxton D. Mitchell,Michael Miller,Jeffrey R. O'Connell,Alan R. Shuldiner,Alan R. Shuldiner +15 more
TL;DR: Mutation carriers compared with noncarriers had lower fasting and postprandial serum triglycerides, higher levels of HDL-ch cholesterol and lower levels of LDL-cholesterol, which suggests that lifelong deficiency of apoC-III has a cardioprotective effect.
Journal ArticleDOI
Acute-Phase Serum Amyloid A: An Inflammatory Adipokine and Potential Link between Obesity and Its Metabolic Complications
Rongze Yang,Mi-Jeong Lee,Hong Hu,Toni I. Pollin,Alice S. Ryan,Barbara J. Nicklas,Soren Snitker,Richard B. Horenstein,Kristen Hull,Nelson H. Goldberg,Andrew P. Goldberg,Alan R. Shuldiner,Alan R. Shuldiner,Susan K. Fried,Susan K. Fried,Da-Wei Gong +15 more
TL;DR: The increased expression of A-SAA by adipocytes in obesity suggests that it may play a critical role in local and systemic inflammation and free fatty acid production and could be a direct link between obesity and its comorbidities, such as insulin resistance and atherosclerosis.
Journal ArticleDOI
Loci associated with ischaemic stroke and its subtypes (SiGN) : A genome-wide association study
Sara L. Pulit,Patrick F. McArdle,Quenna Wong,Rainer Malik,Katrina Gwinn,Sefanja Achterberg,Ale Algra,Philippe Amouyel,Christopher D. Anderson,Donna K. Arnett,Ethem Murat Arsava,John Attia,Hakan Ay,Traci M. Bartz,Thomas W.K. Battey,Oscar R. Benavente,Steve Bevan,Alessandro Biffi,Joshua C. Bis,Susan H. Blanton,Giorgio B. Boncoraglio,Robert D. Brown,Annette I. Burgess,Caty Carrera,Sherita N Chapman Smith,Daniel I. Chasman,Ganesh Chauhan,Wei-Min Chen,Yu-Ching Cheng,Michael Chong,Lisa Cloonan,John W. Cole,Ioana Cotlarciuc,Carlos Cruchaga,Elisa Cuadrado-Godia,Tushar Dave,Jesse Dawson,Stéphanie Debette,Hossein Delavaran,Cameron A Dell,Martin Dichgans,Kimberly F. Doheny,Chuanhui Dong,David Duggan,Gunnar Engström,Michele K. Evans,Xavier Estivill Pallejà,Jessica D. Faul,Israel Fernandez-Cadenas,Myriam Fornage,Philippe M. Frossard,Karen L. Furie,Dale M Gamble,Christian Gieger,Anne-Katrin Giese,Eva Giralt-Steinhauer,Hector M. González,An Goris,Solveig Gretarsdottir,Raji P. Grewal,Ulrike Grittner,Stefan Gustafsson,Buhm Han,Graeme J. Hankey,Laura Heitsch,Peter Higgins,Marc C. Hochberg,Elizabeth G. Holliday,Jemma C. Hopewell,Richard B. Horenstein,George Howard,M. Arfan Ikram,Andreea Ilinca,Erik Ingelsson,Marguerite R. Irvin,Rebecca D. Jackson,Christina Jern,Jordi Jimenez Conde,Julie A. Johnson,Katarina Jood,Muhammad S Kahn,Robert C. Kaplan,L. Jaap Kappelle,Sharon L.R. Kardia,Keith L. Keene,Brett M. Kissela,Dawn Kleindorfer,Simon A. Koblar,Daniel L. Labovitz,Lenore J. Launer,Cathy C. Laurie,Cecelia A. Laurie,Cue Hyunkyu Lee,Jin-Moo Lee,Manuel Lehm,Robin Lemmens,Christopher Levi,Didier Leys,Arne Lindgren,W. T. Longstreth,Jane Maguire,Ani Manichaikul,Hugh S. Markus,Leslie A. McClure,Caitrin W. McDonough,Christa Meisinger,Olle Melander,James F. Meschia,Marina Mola-Caminal,Joan Montaner,Thomas H. Mosley,Martina Müller-Nurasyid,Mike A. Nalls,Jeffrey R. O'Connell,Martin O'Donnell,Angel Ois,George J. Papanicolaou,Guillaume Paré,Leema Reddy Peddareddygari,Annie Pedersen,Joanna Pera,Annette Peters,D Poole,Bruce M. Psaty,Raquel Rabionet,Miriam R. Raffeld,Kristiina Rannikmäe,Asif Rasheed,Petra Redfors,Alexander P. Reiner,Kathryn M. Rexrode,Marta Ribasés,Stephen S. Rich,Wim Robberecht,Ana Rodríguez-Campello,Arndt Rolfs,Jaume Roquer,Lynda M. Rose,Daniel Rosenbaum,Natalia S. Rost,Peter M. Rothwell,Tatjana Rundek,Kathleen A. Ryan,Ralph L. Sacco,Michèle M. Sale,Danish Saleheen,Veikko Salomaa,Cristina Sánchez-Mora,Carsten Oliver Schmidt,Helena Schmidt,Reinhold E. Schmidt,Markus Schürks,Rodney J. Scott,Helen Segal,Stephan Seiler,Sudha Seshadri,Pankaj Sharma,Alan R. Shuldiner,Brian Silver,Agnieszka Slowik,Jennifer A. Smith,Martin Söderholm,Carolina Soriano,Mary J. Sparks,Tara M. Stanne,Kari Stefansson,O. Colin Stine,Konstantin Strauch,Jonathan Sturm,Cathie Sudlow,Salman M. Tajuddin,Robert L. Talbert,Turgut Tatlisumak,Vincent Thijs,Gudmar Thorleifsson,Unnur Thorsteindottir,Steffen Tiedt,Matthew Traylor,Stella Trompet,Valerie Valant,Melanie Waldenberger,Matthew Walters,Liyong Wang,Sylvia Wassertheil-Smoller,David R. Weir,Kerri L. Wiggins,Stephen R. Williams,Dorota Wloch-Kopec,Daniel Woo,Rebecca Woodfield,Ona Wu,Huichun Xu,Alan B. Zonderman,Bradford B. Worrall,Paul I.W. de Bakker,Steven J. Kittner,Braxton D. Mitchell,Jonathan Rosand,Cathie L. M. Sudlow,Bradford B. Worrall,Donna K. Arnett,Oscar R. Benavente,Sylvia Wasssertheil-Smoller +202 more
TL;DR: A novel locus (G allele at rs12122341) at 1p13.2 near TSPAN2 that was associated with large artery atherosclerosis-related stroke was identified and supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies.