M
Matthew Golding
Researcher at Queen Mary University of London
Publications - 38
Citations - 6199
Matthew Golding is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Stem cell & Liver regeneration. The author has an hindex of 23, co-authored 38 publications receiving 5721 citations. Previous affiliations of Matthew Golding include London Research Institute & Imperial College London.
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Journal ArticleDOI
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Holger Gerhardt,Matthew Golding,Marcus Fruttiger,Christiana Ruhrberg,Andrea Lundkvist,Alexandra Abramsson,Michael Jeltsch,Christopher A. Mitchell,Kari Alitalo,David T. Shima,Christer Betsholtz +10 more
TL;DR: It is shown here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts.
Journal ArticleDOI
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
Christiana Ruhrberg,Holger Gerhardt,Matthew Golding,Rose Watson,Sofia Ioannidou,Hajime Fujisawa,Christer Betsholtz,David T. Shima +7 more
TL;DR: It is concluded that differential VEGF-A isoform localization in the extracellular space provides a control point for regulating vascular branching pattern.
Journal ArticleDOI
Deficits in axonal transport precede ALS symptoms in vivo.
Lynsey G. Bilsland,Erik Sahai,Gavin Kelly,Matthew Golding,Linda Greensmith,Giampietro Schiavo +5 more
TL;DR: An in vivo assay that allows the characterization of axonal transport in single axons in the intact sciatic nerve is used and identifies clear axonal Transport deficits in presymptomatic mutant mice, representing one of the earliest axonal pathologies in SOD1G93A mice.
Journal ArticleDOI
VE‐PTP and VE‐cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts
Roman Nawroth,Gregor Poell,Alexander Ranft,Stephan Kloep,Ulrike Samulowitz,Gregor Fachinger,Gregor Fachinger,Matthew Golding,David T. Shima,Urban Deutsch,Urban Deutsch,Dietmar Vestweber,Dietmar Vestweber +12 more
TL;DR: VE‐cadherin is the essential adhesion molecule in endothelial adherens junctions, and the regulation of protein tyrosine phosphorylation is thought to be important for the control of ad herens junction integrity.