H
Håkan Widner
Researcher at Lund University
Publications - 152
Citations - 17373
Håkan Widner is an academic researcher from Lund University. The author has contributed to research in topics: Transplantation & Parkinson's disease. The author has an hindex of 60, co-authored 148 publications receiving 16328 citations. Previous affiliations of Håkan Widner include Karolinska Institutet & Stockholm University.
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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.
Jia-Yi Li,Elisabet Englund,Janice L. Holton,Denis Soulet,Peter Hagell,Andrew J. Lees,Tammaryn Lashley,Niall Quinn,Stig Rehncrona,Anders Björklund,Håkan Widner,Tamas Revesz,Olle Lindvall,Patrik Brundin +13 more
TL;DR: Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11–16 years) developed α-synuclein–positive Lewy bodies in grafted neurons, providing the first evidence, to the authors' knowledge, that the disease can propagate from host to graft cells.
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Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease
Olle Lindvall,Patrik Brundin,Håkan Widner,S Rehncrona,Björn Gustavii,Richard S. J. Frackowiak,Klaus L. Leenders,G. V. Sawle,John C. Rothwell,C. D. Marsden +9 more
TL;DR: The grafts, which were implanted unilaterally into the putamen by stereotactic surgery, restored dopamine synthesis and storage in the grafted area, as assessed by positron emission tomography with 6-L-[18F]fluorodopa.
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Core assessment program for intracerebral transplantations (CAPIT).
J. William Langston,Håkan Widner,Christopher G. Goetz,David J. Brooks,Stanley Fahn,Thomas B. Freeman,Ray L. Watts +6 more
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Core assessment program for surgical interventional therapies in Parkinson's disease (CAPSIT-PD).
TL;DR: A dedicated program entitled “Neurosurgical Interventions in Parkinson's Disease” (NIPD) was funded by the European Union Biomed 2 program to develop a new Core Assessment Program for Surgical Interventional Therapies in PD (CAPSIT‐PD) and to establish an European registry for patients with PD subjected to functional neurosurgery.
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Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient
Paola Piccini,David J. Brooks,Anders Björklund,Roger N. Gunn,Paul M. Grasby,Ornella Rimoldi,Patrik Brundin,Peter Hagell,Stig Rehncrona,Håkan Widner,Olle Lindvall +10 more
TL;DR: Grafted neurons can continue for a decade to store and release dopamine and give rise to substantial symptomatic relief in a patient with Parkinson's disease.