H
Hanan M. Fathy
Researcher at Alexandria University
Publications - 41
Citations - 1771
Hanan M. Fathy is an academic researcher from Alexandria University. The author has contributed to research in topics: Medicine & Exome sequencing. The author has an hindex of 17, co-authored 34 publications receiving 1334 citations. Previous affiliations of Hanan M. Fathy include Fayoum University & Mansoura University.
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Journal ArticleDOI
A Single-Gene Cause in 29.5% of Cases of Steroid-Resistant Nephrotic Syndrome
Carolin E. Sadowski,Svjetlana Lovric,Shazia Ashraf,Werner L. Pabst,Heon Yung Gee,Stefan Kohl,Susanne Engelmann,Virginia Vega-Warner,Humphrey Fang,Jan Halbritter,Michael J. Somers,Weizhen Tan,Shirlee Shril,Inés Fessi,Richard P. Lifton,Detlef Bockenhauer,Sherif M. El-Desoky,Jameela A. Kari,Martin Zenker,Markus J. Kemper,Dominik N Mueller,Hanan M. Fathy,Neveen A. Soliman,Friedhelm Hildebrandt,Friedhelm Hildebrandt +24 more
TL;DR: The study results should facilitate molecular genetic diagnostics of SRNS, etiologic classification for therapeutic studies, generation of genotype-phenotype correlations, and the identification of individuals in whom a targeted treatment for SRNS may be available.
Journal ArticleDOI
ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling
Heon Yung Gee,Pawaree Saisawat,Shazia Ashraf,Toby W. Hurd,Virginia Vega-Warner,Humphrey Fang,Bodo B. Beck,Olivier Gribouval,Weibin Zhou,Katrina A. Diaz,Sivakumar Natarajan,Roger C. Wiggins,Svjetlana Lovric,Gil Chernin,Dominik S. Schoeb,Bugsu Ovunc,Yaacov Frishberg,Neveen A. Soliman,Hanan M. Fathy,Heike Goebel,Julia Hoefele,Lutz T. Weber,Jeffrey W. Innis,Christian Faul,Zhe Han,Joseph Washburn,Corinne Antignac,Shawn Levy,Edgar A. Otto,Friedhelm Hildebrandt +29 more
TL;DR: It is revealed that RHO GTPase signaling is a pathogenic mediator of SRNS and RAC1 inhibitors were partially effective in ameliorating arhgdia-associated defects.
Journal ArticleDOI
Whole Exome Sequencing of Patients with Steroid-Resistant Nephrotic Syndrome
Jillian K. Warejko,Weizhen Tan,Ankana Daga,David Schapiro,Jennifer A. Lawson,Shirlee Shril,Svjetlana Lovric,Shazia Ashraf,Jia Rao,Tobias Hermle,Tilman Jobst-Schwan,Eugen Widmeier,Amar J. Majmundar,Ronen Schneider,Heon Yung Gee,J. Magdalena Schmidt,Asaf Vivante,Amelie T. van der Ven,Hadas Ityel,Jing Chen,Carolin E. Sadowski,Stefan Kohl,Werner L. Pabst,Makiko Nakayama,Michael J. Somers,Nancy Rodig,Ghaleb Daouk,Michelle A. Baum,Deborah R. Stein,Michael A. J. Ferguson,Avram Z. Traum,Neveen A. Soliman,Jameela A. Kari,Sherif El Desoky,Hanan M. Fathy,Martin Zenker,Sevcan A. Bakkaloglu,Dominik N. Müller,Aytül Noyan,Fatih Ozaltin,Melissa A. Cadnapaphornchai,Seema Hashmi,Jeffrey Hopcian,Jeffrey B. Kopp,Nadine Benador,Detlef Bockenhauer,Radovan Bogdanovic,Natasa Stajic,Gil Chernin,Robert B. Ettenger,Henry Fehrenbach,Markus J. Kemper,Reyner Loza Munarriz,Ludmila Podracka,Rainer Büscher,Erkin Serdaroglu,Velibor Tasic,Shrikant Mane,Richard P. Lifton,Daniela A. Braun,Friedhelm Hildebrandt +60 more
TL;DR: W whole exome sequencing is a sensitive approach toward diagnosis of monogenic causes of steroid-resistant nephrotic syndrome.
Journal ArticleDOI
Whole-Exome Sequencing Identifies Causative Mutations in Families with Congenital Anomalies of the Kidney and Urinary Tract.
Amelie T. van der Ven,Dervla M. Connaughton,Hadas Ityel,Nina Mann,Makiko Nakayama,Jing Chen,Asaf Vivante,Daw-Yang Hwang,Julian Schulz,Daniela A. Braun,Johanna Magdalena Schmidt,David Schapiro,Ronen Schneider,Jillian K. Warejko,Ankana Daga,Amar J. Majmundar,Weizhen Tan,Tilman Jobst-Schwan,Tobias Hermle,Eugen Widmeier,Shazia Ashraf,Ali Amar,Charlotte A. Hoogstraaten,Hannah Hugo,Thomas M. Kitzler,Franziska Kause,Caroline M. Kolvenbach,Rufeng Dai,Leslie Spaneas,Kassaundra Amann,Deborah R. Stein,Michelle A. Baum,Michael J. Somers,Nancy Rodig,Michael A. J. Ferguson,Avram Z. Traum,Ghaleb Daouk,Radovan Bogdanovic,Natasa Stajic,Neveen A. Soliman,Jameela A. Kari,Sherif El Desoky,Hanan M. Fathy,Danko Milosevic,Muna Al-Saffar,Muna Al-Saffar,Hazem S. Awad,Loai A. Eid,Aravind Selvin,Prabha Senguttuvan,Simone Sanna-Cherchi,Heidi L. Rehm,Daniel G. MacArthur,Daniel G. MacArthur,Monkol Lek,Monkol Lek,Kristen M. Laricchia,Michael W. Wilson,Shrikant Mane,Richard P. Lifton,Richard P. Lifton,Richard S. Lee,Stuart B. Bauer,Weining Lu,Heiko Reutter,Velibor Tasic,Shirlee Shril,Friedhelm Hildebrandt +67 more
TL;DR: Whole-exome sequencing provides an etiologic diagnosis in a high fraction of patients with CAKUT and will provide a new basis for the mechanistic understanding ofCAKUT.
Journal ArticleDOI
Whole exome sequencing frequently detects a monogenic cause in early onset nephrolithiasis and nephrocalcinosis
Ankana Daga,Amar J. Majmundar,Daniela A. Braun,Heon Yung Gee,Jennifer A. Lawson,Shirlee Shril,Tilman Jobst-Schwan,Asaf Vivante,David Schapiro,Weizhen Tan,Jillian K. Warejko,Eugen Widmeier,Caleb P. Nelson,Hanan M. Fathy,Zoran Gucev,Neveen A. Soliman,Seema Hashmi,Jan Halbritter,Margarita Halty,Jameela A. Kari,Sherif M. El-Desoky,Michael A. J. Ferguson,Michael J. Somers,Avram Z. Traum,Deborah R. Stein,Ghaleb Daouk,Nancy Rodig,Avi Katz,Christian Hanna,Andrew L. Schwaderer,John A. Sayer,Ari J. Wassner,Shrikant Mane,Shrikant Mane,Richard P. Lifton,Richard P. Lifton,Danko Milosevic,Velibor Tasic,Michelle A. Baum,Friedhelm Hildebrandt +39 more
TL;DR: In this article, the authors used whole exome sequencing in 51 families with at least one renal stone or with a renal ultrasound finding of nephrocalcinosis to identify the underlying molecular genetic cause of disease.