Hans-Peter Müller

TL;DR: Neurofilaments in CSF have a high relevance for the differential diagnosis of MNDs and should be included in the diagnostic work-up of patients and their value as prognostic markers should be investigated further.

TL;DR: Diffusion tensor imaging and voxel-based morphometry were used to verify the hypothesis of altered white and gray matter structure in German dyslexic adults and provide exceedingly strong evidence for a disconnection syndrome or dysfunction of cortical areas relevant for reading and spelling.

TL;DR: A new methodological diffusion tensor imaging-based approach to automatically analyse in vivo the fibre tracts that are prone to be involved at each neuropathological stage of amyotrophic lateral sclerosis, enlarges the spectrum of potential non-invasive surrogate markers as a neuroimaging-based read-out for amyotropolitan sclerosis studies within a clinical context.

TL;DR: This large-scale study overcomes the challenges associated with processing and analysis of multiplatform, multicentre DTI data, and effectively demonstrates the anatomical fingerprint patterns of changes in a DTI metric that reflect distinct ALS disease stages.

TL;DR: Serum NFL is increased in ALS in comparison to other conditions and can serve as diagnostic and prognostic biomarker and establish a cut-off level for the diagnosis of ALS.