Markus Otto

TL;DR: How technological advances have enabled the detection of neurofilament proteins in the blood is considered, and how these proteins consequently have the potential to be easily measured biomarkers of neuroaxonal injury in various neurological conditions are discussed.

TL;DR: Neurofilaments in CSF have a high relevance for the differential diagnosis of MNDs and should be included in the diagnostic work-up of patients and their value as prognostic markers should be investigated further.

TL;DR: In this article, the authors found that neurofilaments are elevated in cerebrospinal fluid (CSF) and serum of amyotrophic lateral sclerosis (ALS) patients.

TL;DR: Elevated levels of GFAP in the serum of MS patients correlate with the clinical severity scores and MRI lesion count, especially in PMS patients, and might be a suitable disease progression marker.

TL;DR: Cryo-electron microscopy is used to determine the structure of full-length human HTT in a complex with HTT-associated protein 40 (HAP40; encoded by three F8A genes in humans) to an overall resolution of 4 Å, rationalizing previous biochemical results and paving the way for improved understanding of the diverse cellular functions of HTT.