H
Heiko Braak
Researcher at University of Ulm
Publications - 352
Citations - 80226
Heiko Braak is an academic researcher from University of Ulm. The author has contributed to research in topics: Parkinson's disease & Neurofibrillary tangle. The author has an hindex of 110, co-authored 349 publications receiving 71061 citations. Previous affiliations of Heiko Braak include Katholieke Universiteit Leuven & University of Kiel.
Papers
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C URRENT OPINION Where, when, and in what form does sporadic Alzheimer's disease begin?
Heiko Braak,Kelly Del Tredici +1 more
TL;DR: In this article, a review highlights the earliest phase of the pathological process underlying Alzheimer's disease and highlights the precursory stages of tau pathology in the proximal axon of projection neurons in locus coeruleus.
Book ChapterDOI
Neuropathological hallmarks of Alzheimer's and Parkinson's diseases
TL;DR: In Alzheimer's disease, six developmental stages can be distinguished, reflecting the predictable manner in which the neurofibrillary changes spread through the telencephalic cortex, and in Parkinson's disease lesions also impair portions of the limbic system.
Journal ArticleDOI
Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases.
TL;DR: The gradually evolving lesional pattern in AD and PD mirrors the ground plan of the cerebral cortex, and the severity of the neocortical lesions decreases in inverse proportion to the trajectories of increasing cortical differentiation and hierarchical refinement.
Journal ArticleDOI
Neuropil threads occur in dendrites of tangle-bearing nerve cells.
Heiko Braak,Eva Braak +1 more
TL;DR: Transparent Golgi preparations counterstained for Alzheimer's neurofibrillary changes rendered possible the demonstration of neuropil threads in defined cellular processes.
Journal ArticleDOI
Hot-spot KIF5A mutations cause familial ALS
David A. Brenner,Rüstem Yilmaz,Kathrin Muller,Torsten Grehl,Susanne Petri,Thomas F. Meyer,Julian Grosskreutz,Patrick Weydt,Patrick Weydt,Wolfgang Ruf,Christoph Neuwirth,Markus Weber,Susana Pinto,Kristl G. Claeys,Berthold Schrank,Berit Jordan,Antje Knehr,Kornelia Günther,Annemarie Hübers,Daniel Zeller,Christian Kubisch,Christian Kubisch,Sibylle Jablonka,Michael Sendtner,Thomas Klopstock,Thomas Klopstock,Mamede de Carvalho,Anne D. Sperfeld,Guntram Borck,Alexander E Volk,Alexander E Volk,Johannes Dorst,Joachim Weis,Markus Otto,Joachim Schuster,Kelly Del Tredici,Heiko Braak,Karin M Danzer,Axel Freischmidt,Thomas Meitinger,Thomas Meitinger,Tim M. Strom,Tim M. Strom,Albert C. Ludolph,Peter M. Andersen,Peter M. Andersen,Jochen H. Weishaupt +46 more
TL;DR: Experiments using patient-derived cell lines suggest haploinsufficiency as the molecular genetic mechanism for classical ALS, which underlines the relevance of intracellular transport processes for ALS, and is important for clinico-genetic diagnosis and counselling.