H
Heiko Braak
Researcher at University of Ulm
Publications - 352
Citations - 80226
Heiko Braak is an academic researcher from University of Ulm. The author has contributed to research in topics: Parkinson's disease & Neurofibrillary tangle. The author has an hindex of 110, co-authored 349 publications receiving 71061 citations. Previous affiliations of Heiko Braak include Katholieke Universiteit Leuven & University of Kiel.
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Journal ArticleDOI
Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques
TL;DR: Paired helical filaments, pathologically changed components of the cytoskeleton of human nerve cells, are demonstrated by a specific silver staining technique, immunostaining and electron microscopy.
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Amyotrophic lateral sclerosis—a model of corticofugal axonal spread
Heiko Braak,Johannes Brettschneider,Albert C. Ludolph,Virginia M.-Y. Lee,John Q. Trojanowski,Kelly Del Tredici +5 more
TL;DR: It is posits that the trajectory of the spreading pattern is consistent with the induction and dissemination of pTDP-43 pathology chiefly from cortical neuronal projections, via axonal transport, through synaptic contacts to the spinal cord and other regions of the brain.
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Microbes and Alzheimer's disease
Ruth F. Itzhaki,Ruth F. Itzhaki,Richard Lathe,Brian J. Balin,Melvyn J. Ball,Elaine L. Bearer,Heiko Braak,María J. Bullido,C.J. Carter,Mario Clerici,S. Louise Cosby,Kelly Del Tredici,Hugh J. Field,Tamas Fulop,Claudio Grassi,W. Sue T. Griffin,Jürgen Haas,Alan P. Hudson,Angela R. Kamer,Douglas B. Kell,Federico Licastro,Luc Letenneur,Hugo Lövheim,Roberta Mancuso,Judith Miklossy,Carola Otth,Anna Teresa Palamara,George Perry,Chris M. Preston,Etheresia Pretorius,Timo E. Strandberg,Naji Tabet,Simon D. Taylor-Robinson,Judith A. Whittum-Hudson +33 more
TL;DR: Researchers and clinicians working on Alzheimer’s disease or related topics write to express their concern that one particular aspect of the disease has been neglected.
Journal ArticleDOI
Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis.
Heiko Braak,E. Braak +1 more
TL;DR: It is suggested that the lack of such factors due to premature dysfunction of oligodendrocytes leads to alterations of the neuronal cytoskeleton and eventually to the appearance of Alzheimer-type neurofibrillary changes.
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Staging of Neurofibrillary Pathology in Alzheimer's Disease: A Study of the BrainNet Europe Consortium
Irina Alafuzoff,Thomas Arzberger,Safa Al-Sarraj,Istvan Bodi,Nenad Bogdanovic,Heiko Braak,Orso Bugiani,Kelly Del-Tredici,Isidro Ferrer,Ellen Gelpi,Giorgio Giaccone,Manuel B. Graeber,Paul G. Ince,Wouter Kamphorst,Andrew T. King,Penelope Korkolopoulou,Gabor G. Kovacs,Sergey Larionov,David Meyronet,Camelia M. Monoranu,Piero Parchi,Efstratios Patsouris,Wolfgang Roggendorf,Danielle Seilhean,Fabrizio Tagliavini,Christine Stadelmann,Nathalie Streichenberger,Dietmar Rudolf Thal,Dietmar Rudolf Thal,Stephen B. Wharton,Hans A. Kretzschmar +30 more
TL;DR: The results indicate that good agreement can be reached when the lesions are substantial, i.e., the lesions have reached isocortical structures, whereas when only mild subtle lesions were present the agreement was poorer, and it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers.