Hélène Serra

TL;DR: The utility of fingerprinting single chemicals for an improved understanding of the biological effect of pollutants is demonstrated, and the need to apply bioassays for water quality monitoring is highlighted in order to prevent underestimation of the overall biological effect.

TL;DR: The importance of fingerprinting the effects of detected chemicals is highlighted, as they explain less than 0.2% of the biological effect in the PXR activation, adaptive stress response, and fish embryo toxicity assays.

TL;DR: The majority of bioassays were able to quantitatively detect the predicted non-interactive, additive combined effect of the specifically bioactive compounds against a background of complex mixture of other chemicals in the sample, which supports the use of a combination of chemical and bioanalytical monitoring tools for the identification of chemicals that drive a specific mixture effect.

TL;DR: In vitro and in vivo mechanistic data consistently demonstrated BPB’s capacity to decrease testosterone production and to exert an estrogenic-like activity similar to or greater than BPA's, both pathways being potentially responsible for spermatogenesis impairment in rats and fish.

TL;DR: It is suggested that while modulation of ER-regulated genes by TCS may occur in zebrafish, it does so irrespective of a direct binding and activation of zfERs.