T
Tim D. Williams
Researcher at University of Birmingham
Publications - 45
Citations - 5899
Tim D. Williams is an academic researcher from University of Birmingham. The author has contributed to research in topics: EUROPEAN FLOUNDER & Flounder. The author has an hindex of 27, co-authored 45 publications receiving 5161 citations. Previous affiliations of Tim D. Williams include University of Warwick & Centre for Environment, Fisheries and Aquaculture Science.
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Journal ArticleDOI
High-throughput functional annotation and data mining with the Blast2GO suite.
Stefan Götz,Juan M. García-Gómez,Javier Terol,Tim D. Williams,Shivashankar H. Nagaraj,María José Nueda,Montserrat Robles,Manuel Talon,Joaquín Dopazo,Ana Conesa +9 more
TL;DR: The Blast2GO framework is used to carry out a detailed analysis of annotation behaviour through homology transfer and its impact in functional genomics research to offer biologists useful information to take into account when addressing the task of functionally characterizing their sequence data.
Journal ArticleDOI
Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management.
Rolf Altenburger,Selim Ait-Aissa,Philipp Antczak,Thomas Backhaus,Damià Barceló,Thomas-Benjamin Seiler,François Brion,Wibke Busch,Kevin Chipman,Miren López de Alda,Gisela de Aragão Umbuzeiro,Beate I. Escher,Francesco Falciani,Michael Faust,Andreas Focks,Klára Hilscherová,Juliane Hollender,Henner Hollert,Felix Jäger,Annika Jahnke,Andreas Kortenkamp,Martin Krauss,Gregory F. Lemkine,John Munthe,Steffen Neumann,Emma L. Schymanski,Mark D. Scrimshaw,Helmut Segner,Jaroslav Slobodnik,Foppe Smedes,Subramaniam Kughathas,Ivana Teodorovic,Andrew J. Tindall,Knut Erik Tollefsen,Karl-Heinz Walz,Tim D. Williams,Paul J. Van den Brink,Jos van Gils,Branislav Vrana,Xiaowei Zhang,Werner Brack +40 more
TL;DR: The vision of the international, EU-funded project SOLUTIONS is described, where three routes are explored to link the occurrence of chemical mixtures at specific sites to the assessment of adverse biological combination effects, and comprehensive arrays of effect-based tools and trait-based field observations are explored.
Journal ArticleDOI
A DNA expression array to detect toxic stress response in European flounder (Platichthys flesus).
TL;DR: This study provides a link between traditional single-gene biomarker studies and the emerging field of eco-toxicogenomics, demonstrating the utility of microarray studies on environmentally sampled, non-model organisms.
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Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their Contribution to effects in surface water
Peta A. Neale,Rolf Altenburger,Selim Ait-Aissa,François Brion,Wibke Busch,Gisela de Aragão Umbuzeiro,Michael S. Denison,David Du Pasquier,Klára Hilscherová,Henner Hollert,Daniel Alexandre Morales,Jiří Novák,Rita Schlichting,Thomas-Benjamin Seiler,Hélène Serra,Ying Shao,Andrew J. Tindall,Knut Erik Tollefsen,Tim D. Williams,Beate I. Escher,Beate I. Escher,Beate I. Escher +21 more
TL;DR: The utility of fingerprinting single chemicals for an improved understanding of the biological effect of pollutants is demonstrated, and the need to apply bioassays for water quality monitoring is highlighted in order to prevent underestimation of the overall biological effect.
Journal ArticleDOI
Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model.
Eduarda M. Santos,Jonathan S. Ball,Tim D. Williams,Huifeng Wu,Fernando Ortega,Ronny van Aerle,Ioanna Katsiadaki,Francesco Falciani,Mark R. Viant,James K. Chipman,Charles R. Tyler +10 more
TL;DR: The signaling pathways mediating the effects of exposure to Cu using a toxicogenomic approach in a fish model support the conserved mechanisms of Cu toxicity from lower vertebrates to mammals, provide novel insights into the deleterious effects of Cu in fish, and further demonstrate the utility of fish as environmental sentinels for chemical impacts on both environmental and human health.