H
Henri Brunengraber
Researcher at Case Western Reserve University
Publications - 192
Citations - 7282
Henri Brunengraber is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Citric acid cycle & Gluconeogenesis. The author has an hindex of 44, co-authored 187 publications receiving 6565 citations. Previous affiliations of Henri Brunengraber include Université de Montréal & Massachusetts Institute of Technology.
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Journal ArticleDOI
A roadmap for interpreting 13 C metabolite labeling patterns from cells
Joerg Martin Buescher,Maciek R. Antoniewicz,Laszlo G. Boros,Shawn C. Burgess,Henri Brunengraber,Clary B. Clish,Ralph J. DeBerardinis,Olivier Feron,Christian Frezza,Bart Ghesquière,Eyal Gottlieb,Karsten Hiller,Russell G. Jones,Jurre J. Kamphorst,Richard G. Kibbey,Alec C. Kimmelman,Jason W. Locasale,Sophia Y. Lunt,Oliver D. K. Maddocks,Craig R. Malloy,Christian M. Metallo,Emmanuelle J. Meuillet,Joshua Munger,Katharina Nöh,Joshua D. Rabinowitz,Markus Ralser,Markus Ralser,Uwe Sauer,Gregory Stephanopoulos,Julie St-Pierre,Daniel A. Tennant,Christoph Wittmann,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Alexei Vazquez,Karen H. Vousden,Jamey D. Young,Nicola Zamboni,Sarah-Maria Fendt +38 more
TL;DR: Key issues in interpreting (13)C metabolite labeling patterns are reviewed, with the goal of drawing accurate conclusions from steady state and dynamic stable isotopic tracer experiments.
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Correction of 13C mass isotopomer distributions for natural stable isotope abundance.
TL;DR: Differences between predicted and measured unlabeled and 13C-labeled isotopomer distributions for hydroxamate di-t-butyl-dimethylsilyl (di-TBDMS) derivatized pyruvate were measured and implications including those on the calculation of glucose production due to gluconeogenesis in isolated perfused rat liver are discussed.
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Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting.
Karin Ekberg,Bernard R. Landau,Alexandre Wajngot,Visvanathan Chandramouli,Suad Efendic,Henri Brunengraber,John Wahren +6 more
TL;DR: Gl glucose production by the human kidney in the postabsorptive state makes at most only a minor contribution to blood glucose homeostasis, but that after 60-h of fasting, renal glucose production may account for 20-25% of whole-body glucose turnover.
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Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride
TL;DR: This treatment led rapidly to clinical improvement that included the permanent disappearance of chronic cardiomyopathy, rhabdomyolysis, and muscle weakness in three patients with very-long-chain acyl-CoA dehydrogenase deficiency and opens new avenues for the management of patients with mitochondrial fat oxidation disorders.
Journal ArticleDOI
Assessing Cardiac Metabolism
Heinrich Taegtmeyer,Martin E. Young,Gary D. Lopaschuk,E. Dale Abel,Henri Brunengraber,Victor M. Darley-Usmar,Christine Des Rosiers,Robert E. Gerszten,Jan F. C. Glatz,Julian L. Griffin,Robert J. Gropler,Hermann Georg Holzhuetter,Jorge R. Kizer,E. Douglas Lewandowski,Craig R. Malloy,Stefan Neubauer,Linda R. Peterson,Michael A. Portman,Fabio A. Recchia,Jennifer E. Van Eyk,Thomas J. Wang +20 more
TL;DR: The present statement on "Assessing Cardiac Metabolism" seeks to provide a collective and curated resource on methods and models used to investigate established and emerging aspects of cardiac metabolism.