H
Hervé Lécuyer
Researcher at Necker-Enfants Malades Hospital
Publications - 38
Citations - 1428
Hervé Lécuyer is an academic researcher from Necker-Enfants Malades Hospital. The author has contributed to research in topics: Medicine & Purpura fulminans. The author has an hindex of 16, co-authored 32 publications receiving 1229 citations. Previous affiliations of Hervé Lécuyer include French Institute of Health and Medical Research & Paris Descartes University.
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Journal ArticleDOI
Meningococcal Type IV Pili Recruit the Polarity Complex to Cross the Brain Endothelium
Mathieu Coureuil,Guillain Mikaty,Florence Miller,Florence Miller,Hervé Lécuyer,Hervé Lécuyer,Christine Bernard,Sandrine Bourdoulous,Sandrine Bourdoulous,Guillaume Duménil,René-Marc Mège,Babette B. Weksler,Ignacio A. Romero,Pierre-Olivier Couraud,Pierre-Olivier Couraud,Xavier Nassif,Xavier Nassif +16 more
TL;DR: Type IV pili–mediated adhesion of N. meningitidis to human brain endothelial cells was found to recruit the Par3/Par6/PKCζ polarity complex that plays a pivotal role in the establishment of eukaryotic cell polarity and the formation of intercellular junctions.
Journal ArticleDOI
A journey into the brain: insight into how bacterial pathogens cross blood-brain barriers
Mathieu Coureuil,Mathieu Coureuil,Mathieu Coureuil,Hervé Lécuyer,Sandrine Bourdoulous,Sandrine Bourdoulous,Sandrine Bourdoulous,Xavier Nassif +7 more
TL;DR: This Review focuses on invasive extracellular pathogens, such as Neisseria meningitidis, Streptococcus pneumoniae, group B Streptitiscus and Escherichia coli, to review the obstacles that bacteria have to overcome in order to invade the meninges from the bloodstream, and the specific skills they have developed to bypass the blood–brain barrier.
Journal ArticleDOI
Meningococcus Hijacks a β2-Adrenoceptor/β-Arrestin Pathway to Cross Brain Microvasculature Endothelium
Mathieu Coureuil,Hervé Lécuyer,Hervé Lécuyer,Hervé Lécuyer,Mark G.H. Scott,Mark G.H. Scott,Mark G.H. Scott,Cédric Boularan,Cédric Boularan,Cédric Boularan,Hervé Enslen,Hervé Enslen,Hervé Enslen,Magali Soyer,Guillain Mikaty,Guillain Mikaty,Sandrine Bourdoulous,Sandrine Bourdoulous,Sandrine Bourdoulous,Xavier Nassif,Xavier Nassif,Xavier Nassif,Stefano Marullo,Stefano Marullo,Stefano Marullo +24 more
TL;DR: The identification of the mechanism used for hijacking host cell signaling machineries opens perspectives for treatment and prevention of meningococcal infection.
Journal ArticleDOI
Evaluation of the Andromas Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System for Identification of Aerobically Growing Gram-Positive Bacilli
E. Farfour,E. Farfour,J. Leto,M. Barritault,M. Barritault,Claudia Barberis,Julie Meyer,Brunhilde Dauphin,A.-S. Le Guern,Anne Leflèche,Edgar Badell,Nicole Guiso,Alexandre Leclercq,A. Le Monnier,Marc Lecuit,Marc Lecuit,Veronica Rodriguez-Nava,Emmanuelle Bergeron,Josette Raymond,S. Vimont,Emmanuelle Bille,Emmanuelle Bille,E. Carbonnelle,E. Carbonnelle,Hélène Guet-Revillet,Hélène Guet-Revillet,Hervé Lécuyer,Hervé Lécuyer,Jean-Luc Beretti,Jean-Luc Beretti,Carlos Vay,Patrick Berche,Patrick Berche,Agnès Ferroni,Agnès Ferroni,Xavier Nassif,Xavier Nassif,Olivier Join-Lambert,Olivier Join-Lambert +38 more
TL;DR: Data demonstrate that rapid identification of pathogenic GPRs can be obtained without an extraction step by MALDI-TOF mass spectrometry.
Journal ArticleDOI
Carbapenem-Hydrolyzing GES-Type Extended-Spectrum β-Lactamase in Acinetobacter baumannii
Rémy A. Bonnin,Patrice Nordmann,Anaïs Potron,Anaïs Potron,Hervé Lécuyer,Jean-Ralph Zahar,Laurent Poirel +6 more
TL;DR: This study identified a very broad-spectrum β-lactamase in A. baumannii that compromised significantly the efficacy of all β- lactams, including cephalosporins, aztreonam, and carbapenems.