H
Hideo Hayashi
Researcher at University of Tsukuba
Publications - 69
Citations - 5804
Hideo Hayashi is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Gene & Clostridium perfringens. The author has an hindex of 34, co-authored 68 publications receiving 5604 citations.
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Journal ArticleDOI
Whole genome sequencing of meticillin-resistant Staphylococcus aureus
Makoto Kuroda,Toshiko Ohta,Ikuo Uchiyama,Tadashi Baba,Harumi Yuzawa,Ichizo Kobayashi,Longzhu Cui,Akio Oguchi,Ken-ichi Aoki,Yoshimi Nagai,JianQi Lian,Teruyo Ito,Mutsumi Kanamori,Hiroyuki Matsumaru,Atsushi Maruyama,Hiroyuki Murakami,Akira Hosoyama,Yoko Mizutani-Ui,Noriko K. Takahashi,Toshihiko Sawano,Ryu-ichi Inoue,Chikara Kaito,Kazuhisa Sekimizu,Hideki Hirakawa,Satoru Kuhara,Susumu Goto,Junko Yabuzaki,Minoru Kanehisa,Atsushi Yamashita,Kenshiro Oshima,Keiko Furuya,Chie Yoshino,Tadayoshi Shiba,Masahira Hattori,Naotake Ogasawara,Hideo Hayashi,Keiichi Hiramatsu +36 more
TL;DR: Investigation of many newly identified gene products, including the 70 putative virulence factors, will greatly improve the understanding of the biology of staphylococci and the processes of infectious diseases caused by S aureus.
Journal ArticleDOI
Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater
Tohru Shimizu,Kaori Ohtani,Hideki Hirakawa,Kenshiro Ohshima,Atsushi Yamashita,Tadayoshi Shiba,Naotake Ogasawara,Masahira Hattori,Satoru Kuhara,Hideo Hayashi +9 more
TL;DR: The genome analysis proved an efficient method for finding four members of the two-component VirR/VirS regulon that coordinately regulates the pathogenicity of C. perfringens, and a total of five hyaluronidase genes that will also contribute to virulence.
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Genome Sequence of an M3 Strain of Streptococcus pyogenes Reveals a Large-Scale Genomic Rearrangement in Invasive Strains and New Insights into Phage Evolution
Ichiro Nakagawa,Ken Kurokawa,Atsushi Yamashita,Masanobu Nakata,Yusuke Tomiyasu,Nobuo Okahashi,Shigetada Kawabata,Kiyoshi Yamazaki,Tadayoshi Shiba,Teruo Yasunaga,Hideo Hayashi,Masahira Hattori,Shigeyuki Hamada +12 more
TL;DR: Observations indicate that streptococcal phages represent important plasticity regions in the GAS chromosome where recombination between homologous phage genes can occur and result not only in new phage derivatives, but also in large chromosomal rearrangements.
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The luxS gene is involved in cell-cell signalling for toxin production in Clostridium perfringens.
TL;DR: The results indicate that cell–cell signalling by AI‐2 plays an important role in the regulation of toxin production in C. perfringens.
Journal ArticleDOI
The virR gene, a member of a class of two-component response regulators, regulates the production of perfringolysin O, collagenase, and hemagglutinin in Clostridium perfringens.
TL;DR: A homology search for the deduced amino acid sequence revealed that ORF2 was homologous to a response regulator in a two-component signal transduction system, and it is suggested that the virR gene plays an important role in the pathogenicity of C. perfringens.