H
Hiroaki Itamochi
Researcher at Iwate Medical University
Publications - 134
Citations - 3836
Hiroaki Itamochi is an academic researcher from Iwate Medical University. The author has contributed to research in topics: Ovarian cancer & Cancer. The author has an hindex of 33, co-authored 132 publications receiving 3425 citations. Previous affiliations of Hiroaki Itamochi include Tottori University & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
A Link between mir-100 and FRAP1/mTOR in Clear Cell Ovarian Cancer
Ankur K. Nagaraja,Chad J. Creighton,Zhifeng Yu,Huifeng Zhu,Preethi H. Gunaratne,Preethi H. Gunaratne,Jeffrey G. Reid,Jeffrey G. Reid,Emuejevoke Olokpa,Hiroaki Itamochi,Naoto T. Ueno,Shannon M. Hawkins,Matthew L. Anderson,Martin M. Matzuk +13 more
TL;DR: Strong candidate miRNAs and their target genes that may contribute to the pathogenesis of clear cell ovarian cancer are revealed, thereby highlighting alternative therapeutic strategies for the treatment of this deadly cancer.
Journal ArticleDOI
Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma.
TL;DR: The current state of knowledge of the chemoresistance mechanism in CCC is discussed and novel treatment strategies for CCC are discussed.
Journal Article
Correlation between Loss of PTEN Expression and Akt Phosphorylation in Endometrial Carcinoma
Yasunobu Kanamori,Junzo Kigawa,Hiroaki Itamochi,Muneaki Shimada,Masakuni Takahashi,Syunji Kamazawa,Shinya Sato,Ryoji Akeshima,Naoki Terakawa +8 more
TL;DR: The present study demonstrates the phosphorylation of Akt accompanied by the loss of PTEN in clinical specimens of endometrial carcinomas, demonstrating the inverse correlation between PTEN and phospho-Akt.
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Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling
Pau Creixell,Erwin M. Schoof,Craig D. Simpson,James Longden,Chad J. Miller,Hua Jane Lou,Lara Perryman,Thomas R. Cox,Nevena Zivanovic,Antonio Palmeri,Agata Wesolowska-Andersen,Manuela Helmer-Citterich,Jesper Ferkinghoff-Borg,Hiroaki Itamochi,Bernd Bodenmiller,Janine T. Erler,Benjamin E. Turk,Rune Linding,Rune Linding +18 more
TL;DR: Six types of network-attacking mutations (NAMs) are identified, including changes in kinase and SH2 modulation, network rewiring, and the genesis and extinction of phosphorylation sites, and mutant molecular logic gates and kinase-inactivating hotspots in cancer are discovered.
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High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway
Kosuke Yoshihara,Tatsuhiko Tsunoda,Daichi Shigemizu,Hiroyuki Fujiwara,Masayuki Hatae,Hisaya Fujiwara,Hideaki Masuzaki,Hidetaka Katabuchi,Yosuke Kawakami,Aikou Okamoto,Takayoshi Nogawa,Noriomi Matsumura,Yasuhiro Udagawa,Tsuyoshi Saito,Hiroaki Itamochi,Masashi Takano,Etsuko Miyagi,Tamotsu Sudo,Kimio Ushijima,Haruko Iwase,Hiroyuki Seki,Yasuhisa Terao,Takayuki Enomoto,Mikio Mikami,Kohei Akazawa,Hitoshi Tsuda,Takuya Moriya,Atsushi Tajima,Ituro Inoue,Kenichi Tanaka +29 more
TL;DR: Through gene ontology and pathway analyses, a significant reduction in expression of immune-response–related genes, especially on the antigen presentation pathway, in high-risk ovarian cancer patients is identified.