H
Hiroki Shimogawa
Researcher at Kyoto University
Publications - 5
Citations - 240
Hiroki Shimogawa is an academic researcher from Kyoto University. The author has contributed to research in topics: Induced pluripotent stem cell & Neural cell adhesion molecule. The author has an hindex of 5, co-authored 5 publications receiving 215 citations.
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Journal ArticleDOI
Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma
Atsushi Natsume,Motokazu Ito,Keisuke Katsushima,Fumiharu Ohka,Akira Hatanaka,Keiko Shinjo,Shinya Sato,Satoru Takahashi,Yuta Ishikawa,Ichiro Takeuchi,Hiroki Shimogawa,Motonari Uesugi,Hideyuki Okano,Seung U. Kim,Toshihiko Wakabayashi,Jean Pierre J. Issa,Y Sekido,Yutaka Kondo +17 more
TL;DR: Results indicate that epigenetic regulation by PRC2 is a key mediator of tumor cell plasticity, which is required for the adaptation of glioblastoma cells to their microenvironment, andPRC2-targeted therapy may reduce tumor cell Plasticity and tumor heterogeneity, offering a new paradigm for glioma treatment.
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A Mitochondrial Surface‐Specific Fluorescent Probe Activated by Bioconversion
TL;DR: Kawazoe, Y.
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Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.
Shinji Kamisuki,Takashi Shirakawa,Akira Kugimiya,Lutfi Abu-Elheiga,Hea-Young Park Choo,Kouhei Yamada,Hiroki Shimogawa,Salih J. Wakil,Motonari Uesugi,Motonari Uesugi +9 more
TL;DR: The structure-activity relationships led to the identification of N-(4-(2-propylpyridin-4-yl)thiazol-4,yl)phenyl)methanesulfonamide (24, FGH10019) as the most potent druglike molecule among the analogues tested.
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A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth
TL;DR: Chemical and cell biological experiments suggest that the diaryldispirotripiperazine derivative (adhesamine) targets selective cell-surface glycosaminoglycans, especially heparan sulfate, for increasing cell adhesion and growth.
Journal ArticleDOI
Selective elimination of human pluripotent stem cells by a marine natural product derivative.
Ting-Fang Kuo,Di Mao,Nao Hirata,Bilon Khambu,Yasuhisa Kimura,Eihachiro Kawase,Hiroki Shimogawa,Makoto Ojika,Norio Nakatsuji,Kazumitsu Ueda,Motonari Uesugi +10 more
TL;DR: The results demonstrate that selective elimination of human pluripotent stem cells can be achieved by designing cytotoxic small molecules with appropriate ABC-transporter selectivity.