T
Toshiya Sato
Researcher at Kitasato University
Publications - 26
Citations - 1460
Toshiya Sato is an academic researcher from Kitasato University. The author has contributed to research in topics: Dentatorubral-pallidoluysian atrophy & Neuropathology. The author has an hindex of 14, co-authored 25 publications receiving 1397 citations. Previous affiliations of Toshiya Sato include Niigata University.
Papers
More filters
Journal ArticleDOI
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription.
Takayoshi Shimohata,Toshihiro Nakajima,Mitsunori Yamada,Chiharu Uchida,Osamu Onodera,Satoshi Naruse,T. Kimura,Reiji Koide,Kenkichi Nozaki,Yasuteru Sano,Hiroshi Ishiguro,Kumi Sakoe,Takayuki Ooshima,Aki Sato,Takeshi Ikeuchi,Mutsuo Oyake,Toshiya Sato,Yasuyuki Aoyagi,Isao Hozumi,Toshiharu Nagatsu,Yoshihisa Takiyama,Masatoyo Nishizawa,Jun Goto,Ichiro Kanazawa,Irwin Davidson,Naoko Tanese,Hitoshi Takahashi,Shoji Tsuji +27 more
TL;DR: Results indicate that interference of transcription by the binding of TAFII130 with expanded polyQ stretches is involved in the pathogenetic mechanisms underlying neurodegeneration.
Journal ArticleDOI
Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.
Shuichi Igarashi,Reiji Koide,Takayoshi Shimohata,Mitsunori Yamada,Yasuko Hayashi,Hiroki Takano,Hidetoshi Date,Mutsuo Oyake,Toshiya Sato,Aki Sato,Shigekimi Egawa,Takeshi Ikeuchi,Hajime Tanaka,Ryoichi Nakano,Keiko Tanaka,Isao Hozumi,Takashi Inuzuka,Hitoshi Takahashi,Shoji Tsuji +18 more
TL;DR: It is found that truncated DRPLA proteins containing an expanded polyglutamine stretch form filamentous peri- and intranuclear aggregates and undergo apoptosis, suggesting involvement of a transglutaminase reaction and providing a potential basis for the development of therapeutic measures for CAG-repeat expansion diseases.
Journal ArticleDOI
CAG repeat disorder models and human neuropathology: similarities and differences.
TL;DR: Although there are no models that fully represent the neuropathologic changes present in humans, the data obtained have provided evidence that clinical onset is not clearly associated with neuronal cell death, but depends on intranuclear accumulation of mutant proteins in neurons.
Journal ArticleDOI
Transgenic Mice Harboring a Full-Length Human Mutant DRPLA Gene Exhibit Age-Dependent Intergenerational and Somatic Instabilities of CAG repeats Comparable with Those in DRPLA patients
Toshiya Sato,Mutsuo Oyake,Kenji Nakamura,Kazuki Nakao,Yoshimitsu Fukusima,Osamu Onodera,Shuichi Igarashi,Hiroki Takano,Koki Kikugawa,Yoshinori Ishida,Takayoshi Shimohata,Reiji Koide,Takeshi Ikeuchi,Hajime Tanaka,Naonobu Futamura,Ryusuke Matsumura,Tetsuya Takayanagi,Fumiaki Tanaka,Gen Sobue,Osamu Komure,Mie Takahashi,Akira Sano,Yaeko Ichikawa,Jun Goto,Ichiro Kanazawa,Motoya Katsuki,Shoji Tsuji +26 more
TL;DR: The transgenic mice described in this study exhibited age-dependent intergenerational as well as somatic instabilities of expanded CAG repeats comparable with those observed in human DRPLA patients, and are expected to serve as good models for investigating the molecular mechanisms of instabilities in CAG repeat instability.
Journal ArticleDOI
Chondroitin sulphate N -acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury
Kosei Takeuchi,Nozomu Yoshioka,Susumu Higa Onaga,Yumi Watanabe,Yumi Watanabe,Shinji Miyata,Yoshino Wada,Chika Kudo,Masayasu Okada,Kentaro Ohko,Kanako Oda,Toshiya Sato,Minesuke Yokoyama,Natsuki Matsushita,Masaya Nakamura,Hideyuki Okano,Kenji Sakimura,Hitoshi Kawano,Hiroshi Kitagawa,Michihiro Igarashi +19 more
TL;DR: Results indicate that regulation of a single gene, T1, mediates excellent recovery from spinal cord injury by optimizing counteracting effectors of axon regeneration—an extracellular inhibitor of CS and intrinsic promoters, namely, HS-synthesis enzymes.