H
Hiroshi Sakura
Researcher at University of Tokyo
Publications - 44
Citations - 2897
Hiroshi Sakura is an academic researcher from University of Tokyo. The author has contributed to research in topics: Diabetes mellitus & Insulin. The author has an hindex of 20, co-authored 41 publications receiving 2803 citations.
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Journal ArticleDOI
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.
Hiroyuki Tamemoto,Takashi Kadowaki,Kazuyuki Tobe,Takeshi Yagi,Hiroshi Sakura,Takaki Hayakawa,Takaki Hayakawa,Yasuo Terauchi,Kohjiro Ueki,Yasushi Kaburagi,Shinobu Satoh,Hisahiko Sekihara,Shinji Yoshioka,Hiroyoshi Horikoshi,Yasuhide Furuta,Yoji Ikawa,Masato Kasuga,Yoshio Yazaki,Shinichi Aizawa +18 more
TL;DR: The data suggest that mice homozygous for targeted disruption of the IRS-1 gene were born alive but were retarded in embryonal and postnatal growth and the exis-tence of both IRS- 1-dependent and IRS-2-independent pathways for signal transduction of insulin and IGFs is suggested.
Journal ArticleDOI
A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA
Takashi Kadowaki,Hiroko Kadowaki,Y Mori,Kazuyuki Tobe,Ryoichi Sakuta,Yuusuke Suzuki,Y Tanabe,Hiroshi Sakura,Takuya Awata,Yu-ichi Goto +9 more
TL;DR: Diabetes mellitus associated with the A-->G mutation at position 3243 of mitochondrial leucine transfer RNA represents a subtype of diabetes found in both patients with IDDM and patients with NIDDM in Japan.
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Pancreatic β-Cell-specific Targeted Disruption of Glucokinase Gene DIABETES MELLITUS DUE TO DEFECTIVE INSULIN SECRETION TO GLUCOSE
Yasuo Terauchi,Hiroshi Sakura,Kazuki Yasuda,Keiji Iwamoto,Noriko Takahashi,Kouichi Ito,Haruo Kasai,Hiroshi Suzuki,Otoya Ueda,Nobuo Kamada,Kou-ichi Jishage,Kajuro Komeda,Mitsuhiko Noda,Yasunori Kanazawa,Shigeki Taniguchi,Ichitomo Miwa,Yasuo Akanuma,Tatsuhiko Kodama,Yoshio Yazaki,Takashi Kadowaki +19 more
TL;DR: GK-deficient mice serve as an animal model of the insulin-secretory defect in human non-insulin-dependent diabetes mellitus and provide the first direct proof that GK serves as a glucose sensor molecule for insulin secretion and plays a pivotal role in glucose homeostasis.
Journal ArticleDOI
Ethidium Bromide-induced Inhibition of Mitochondrial Gene Transcription Suppresses Glucose-stimulated Insulin Release in the Mouse Pancreatic β-Cell Line βHC9
Takaki Hayakawa,Mitsuhiko Noda,Mitsuhiko Noda,Kazuki Yasuda,Hiroshi Yorifuji,Shigeki Taniguchi,Ichitomo Miwa,Hiroshi Sakura,Yasuo Terauchi,Jun-Ichi Hayashi,Geoffrey W. G. Sharp,Yasunori Kanazawa,Yasuo Akanuma,Yoshio Yazaki,Takashi Kadowaki +14 more
TL;DR: Investigation of the involvement of mitochondrial function in insulin secretion in pancreatic β-cell line with low dose ethidium bromide revealed that treatment by EB caused morphological changes only in mitochondria and not in other organelles such as nuclei, endoplasmic reticula, Golgi bodies, or secretory granules.
Journal ArticleDOI
Decreased response inhibition in middle-aged male patients with type 2 diabetes
TL;DR: The results showed that middle-aged, newly diagnosed and medication-free patients with type 2 diabetes have a particular neuropsychological deficit in inhibitory control of impulsive response, which is an independent effect of diabetes apart from being overweight.