H
Hiroyuki Tamemoto
Researcher at University of Tokyo
Publications - 39
Citations - 6561
Hiroyuki Tamemoto is an academic researcher from University of Tokyo. The author has contributed to research in topics: Insulin receptor & Insulin. The author has an hindex of 29, co-authored 39 publications receiving 6443 citations. Previous affiliations of Hiroyuki Tamemoto include National Institutes of Health & Gunma University.
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Journal ArticleDOI
PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance
Naoto Kubota,Yasuo Terauchi,Hiroshi Miki,Hiroyuki Tamemoto,Hiroyuki Tamemoto,Toshimasa Yamauchi,Kajuro Komeda,Shinobu Satoh,Ryosuke Nakano,Chikara Ishii,Takuya Sugiyama,Kazuhiro Eto,Yoshiharu Tsubamoto,Akira Okuno,Koji Murakami,Hisahiko Sekihara,Go Hasegawa,Makoto Naito,Yasushi Toyoshima,Satoshi Tanaka,Kunio Shiota,Toshio Kitamura,Toshiro Fujita,Osamu Ezaki,Shinichi Aizawa,Ryozo Nagai,Kazuyuki Tobe,Satoshi Kimura,Takashi Kadowaki +28 more
TL;DR: A hitherto unpredicted role for PPARγ in high-fat diet–induced obesity due to adipocyte hypertrophy and insulin resistance, which requires both alleles of PPARα, is revealed.
Journal ArticleDOI
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.
Hiroyuki Tamemoto,Takashi Kadowaki,Kazuyuki Tobe,Takeshi Yagi,Hiroshi Sakura,Takaki Hayakawa,Takaki Hayakawa,Yasuo Terauchi,Kohjiro Ueki,Yasushi Kaburagi,Shinobu Satoh,Hisahiko Sekihara,Shinji Yoshioka,Hiroyoshi Horikoshi,Yasuhide Furuta,Yoji Ikawa,Masato Kasuga,Yoshio Yazaki,Shinichi Aizawa +18 more
TL;DR: The data suggest that mice homozygous for targeted disruption of the IRS-1 gene were born alive but were retarded in embryonal and postnatal growth and the exis-tence of both IRS- 1-dependent and IRS-2-independent pathways for signal transduction of insulin and IGFs is suggested.
Journal ArticleDOI
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.
Akira Okuno,Hiroyuki Tamemoto,Kazuyuki Tobe,Kohjiro Ueki,Yasumichi Mori,Keiji Iwamoto,Kazuhiko Umesono,Yasuo Akanuma,Fujiwara Toshihiko,Hiroyoshi Horikoshi,Yoshio Yazaki,Takashi Kadowaki +11 more
TL;DR: The increased number of small adipocytes and the decreased number of large adipocytes in white adipose tissues of troglitazone-treated obese rats appear to be an important mechanism by which increased expression levels of TNF-alpha and higher levels of plasma lipids are normalized, leading to alleviation of insulin resistance.
Journal ArticleDOI
Parthenogenetic activation of oocytes in c-mos-deficient mice
Naohiro Hashimoto,Nobumoto Watanabe,Yasuhide Furuta,Hiroyuki Tamemoto,Noriyuiki Sagata,Minesuke Yokoyama,Kenji Okazaki,Mariko Nagayoshi,Naoki Takeda,Yoji Ikawa,Shinichi Aizawa +10 more
TL;DR: Results indicate that in mice Mos plays a role in the second meiotic metaphase arrest, but does not seem to be essential for the initiation of oocyte maturation, spermatogenesis or somatic cell cycle.
Journal ArticleDOI
Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes.
Tsutomu Yamazaki,Kazuyuki Tobe,Eitetsu Hoh,Kouji Maemura,T Kaida,Issei Komuro,Hiroyuki Tamemoto,Takashi Kadowaki,R. Nagai,Yoshio Yazaki +9 more
TL;DR: It is concluded that myocyte stretching increases the activities of MAP kinase and S6 peptide kinase, which may play an important role in the induction of the specific genes and the increase in the protein synthesis.