Ho Minh Ly

TL;DR: The results suggests the existence of fine geographical genetic clines within MTC populations, that could mirror the passed and present Homo sapiens sapiens demographical and mycobacterial co-evolutionary history whose structure could be further reconstructed and modelled, thereby providing a large-scale conceptual framework of the global TB Epidemiologic Network.

TL;DR: To facilitate the analysis of hundreds of spoligotypes each made up of a binary succession of 43 bits of information, a number of major and minor visual rules were also defined to define 36 major clades (or families) of M. tuberculosis.

TL;DR: This global distribution was defined by data-mining of an international spoligotyping database, SpolDB3, which contains 11,708 patterns from as many clinical isolates originating from more than 90 countries.

TL;DR: It is hypothesized that two key events shaped the early history of the Beijing genotype: its Upper Palaeolithic origin in the Homo sapiens sapiens K-M9 cluster in Central Asia, and primary Neolithic dispersal of the secondary Beijing NTF::IS6110 lineage by Proto-Sino-Tibetan farmers within east Asia.

TL;DR: This work suggests using IS6110-based inverse-PCR typing for the correct identification of the Beijing genotype and its major sublineages, which is fast and inexpensive and does not require additional experiments.