T
Troels Lillebaek
Researcher at Statens Serum Institut
Publications - 124
Citations - 5781
Troels Lillebaek is an academic researcher from Statens Serum Institut. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 27, co-authored 107 publications receiving 4742 citations. Previous affiliations of Troels Lillebaek include Hvidovre Hospital & Copenhagen University Hospital.
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Journal ArticleDOI
Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
Karine Brudey,Jeffrey Driscoll,Leen Rigouts,Wolfgang M. Prodinger,Andrea Gori,Sahal Al-Hajoj,Caroline Allix,Liselotte Aristimuño,Jyoti Arora,Viesturs Baumanis,Lothar Binder,Patrícia Izquierdo Cafrune,Ángel Adrián Cataldi,Soonfatt Cheong,Roland Diel,Christopher Ellermeier,Jason T. Evans,Maryse Fauville-Dufaux,Séverine Ferdinand,Darío García de Viedma,Carlo Garzelli,Lidia Gazzola,Harrison Magdinier Gomes,M Cristina Guttierez,Peter M. Hawkey,Paul D. van Helden,Gurujaj V Kadival,Barry N. Kreiswirth,Kristin Kremer,Milan Kubin,Savita Kulkarni,Benjamin Liens,Troels Lillebaek,Ho Minh Ly,Carlos Martin,Christian Martin,Igor Mokrousov,Narvskaia Ov,Yun Fong Ngeow,Ludmilla Naumann,Stefan Niemann,Ida Parwati,Zeaur Rahim,Voahangy Rasolofo-Razanamparany,T. Rasolonavalona,M Lucia Rossetti,Sabine Rüsch-Gerdes,Anna Sajduda,Sofía Samper,Igor G Shemyakin,Urvashi B. Singh,Akos Somoskovi,Robin A. Skuce,Dick van Soolingen,Streicher Em,Philip Noel Suffys,Enrico Tortoli,Tatjana Tracevska,Véronique Vincent,Tommie C. Victor,Robin M. Warren,Sook Fan Yap,Khadiza Zaman,Françoise Portaels,Nalin Rastogi,Christophe Sola +65 more
TL;DR: The results suggests the existence of fine geographical genetic clines within MTC populations, that could mirror the passed and present Homo sapiens sapiens demographical and mycobacterial co-evolutionary history whose structure could be further reconstructed and modelled, thereby providing a large-scale conceptual framework of the global TB Epidemiologic Network.
Journal ArticleDOI
Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
Matthias Merker,Camille Blin,Stefano Mona,Nicolas Duforet-Frebourg,Sophie Lecher,Eve Willery,Michael G. B. Blum,Sabine Rüsch-Gerdes,Igor Mokrousov,Eman Aleksic,Caroline Allix-Béguec,Annick Antierens,Ewa Augustynowicz-Kopeć,Marie Ballif,Francesca Barletta,Hans P eter Beck,Clifton E. Barry,Maryline Bonnet,Emanuele Borroni,Isolina Campos-Herrero,Daniela Maria Cirillo,Helen Cox,Suzanne M. Crowe,Valeriu Crudu,Roland Diel,Francis Drobniewski,Maryse Fauville-Dufaux,Sebastien Gagneux,Solomon Ghebremichael,Madeleine Hanekom,Sven Hoffner,Wei wei Jiao,Stobdan Kalon,Thomas Kohl,Irina Kontsevaya,Troels Lillebaek,Shinji Maeda,Vladyslav Nikolayevskyy,Michael Rasmussen,Nalin Rastogi,Sofía Samper,Elisabeth Sanchez-Padilla,Branislava Savic,Isdore Chola Shamputa,Adong Shen,Li Hwei Sng,Petras Stakenas,Kadri Toit,Francis Varaine,Dragana Vuković,Céline Wahl,Robin M. Warren,Philip Supply,Stefan Niemann,Thierry Wirth +54 more
TL;DR: It is shown that this lineage of mycobacterium tuberculosis strains of the Beijing lineage initially originated in the Far East, from where it radiated worldwide in several waves and detected successive increases in population size over the last 200 years.
Journal ArticleDOI
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.
Josephine M. Bryant,Josephine M. Bryant,Dorothy M Grogono,Dorothy M Grogono,Daniela Rodriguez-Rincon,Isobel Everall,Karen Brown,Karen Brown,Pablo Moreno,Deepshikha Verma,Emily Hill,Judith Drijkoningen,Peter H. Gilligan,Charles R. Esther,Peadar G. Noone,Olivia Giddings,Scott C. Bell,Scott C. Bell,Rachel Thomson,Claire E. Wainwright,Claire E. Wainwright,Chris Coulter,Sushil Pandey,Michelle Wood,Michelle Wood,Rebecca E Stockwell,Rebecca E Stockwell,Kay A. Ramsay,Kay A. Ramsay,Laura J. Sherrard,Timothy J. Kidd,Timothy J. Kidd,Nassib Jabbour,Graham R. Johnson,Luke D. Knibbs,Lidia Morawska,Peter D. Sly,Andrew Jones,Diana Bilton,Ian F. Laurenson,Michael Ruddy,Stephen Bourke,Ian C. J. W. Bowler,Stephen J Chapman,Andrew Clayton,Mairi Cullen,Owen J. Dempsey,Miles Denton,M. Desai,Richard J Drew,Frank Edenborough,Jason T. Evans,Jonathan Folb,Thomas Daniels,Helen Humphrey,Barbara Isalska,Søren Jensen-Fangel,Bodil Jönsson,Andrew M Jones,Terese L. Katzenstein,Troels Lillebaek,Gordon MacGregor,Sarah Mayell,Michael Millar,Deborah E. Modha,Edward F. Nash,C. O'Brien,Deirdre O'Brien,Chandra Ohri,Caroline S. Pao,Daniel Peckham,Felicity Perrin,Audrey Perry,Tania Pressler,Laura Prtak,Tavs Qvist,Ali Robb,Helen Rodgers,Kirsten Schaffer,Nadia Shafi,Jakko van Ingen,Martin Walshaw,Danie Watson,Noreen West,Joanna L. Whitehouse,Charles S. Haworth,Simon R. Harris,Diane J. Ordway,Julian Parkhill,R. Andres Floto,R. Andres Floto +90 more
TL;DR: Using whole-genome analysis of a global collection of clinical isolates, it is shown that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally.
Journal ArticleDOI
Comparison of tuberculin skin test and new specific blood test in tuberculosis contacts
TL;DR: The QTF-TB test addresses the operational problems with the tuberculin skin test, but it still has a low specificity in populations vaccinated with the Bacille Calmette-Guérin (BCG) vaccine.
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
Josephine M. Bryant,Dorothy M Grogono,Daniela Rodriguez-Rincon,Isobel Everall,Karen Brown,Pablo Moreno,Deepshikha Verma,E. Hill,J. Drijkoningen,Peter H. Gilligan,Charles R. Esther,Peadar G. Noone,Olivia Giddings,Scott C. Bell,Rachel Thomson,Claire E. Wainwright,Chris Coulter,Sushil Pandey,Michelle Wood,Rebecca E Stockwell,Kay A. Ramsay,Laura J. Sherrard,Timothy J. Kidd,Nassib Jabbour,Graham R. Johnson,Luke D. Knibbs,Lidia Morawska,Peter D. Sly,Alison Jones,Diana Bilton,Ian F. Laurenson,Michael Ruddy,Stephen Bourke,Ian C. J. W. Bowler,Stephen J Chapman,Andrew Clayton,M. Cullen,Owen J. Dempsey,Miles Denton,M. Desai,R. J. Drew,F. Edenborough,Jason T. Evans,Jonathan Folb,T. Daniels,H. Humphrey,B. Isalska,Søren Jensen-Fangel,Bodil Jönsson,Andrew Jones,Terese L. Katzenstein,Troels Lillebaek,Gordon MacGregor,S. Mayell,Michael Millar,Deborah E. Modha,Edward F. Nash,C. O'Brien,D. OBrien,Chandra Ohri,Caroline S. Pao,Daniel Peckham,Felicity Perrin,Audrey Perry,Tacjana Pressler,L. Prtak,Tavs Qvist,A. Robb,Helen Rodgers,K. Schaffer,Nadia Shafi,J. van Ingen,M. Walshaw,D. Watson,Noreen West,Joanna L. Whitehouse,Charles S. Haworth,Simon R. Harris,Diane J. Ordway,Julian Parkhill,R.A. Floto +80 more
TL;DR: In this paper, the authors used whole-genome analysis of a global collection of clinical isolates to show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones.