H
Howard D. Lipshitz
Researcher at University of Toronto
Publications - 102
Citations - 9700
Howard D. Lipshitz is an academic researcher from University of Toronto. The author has contributed to research in topics: Maternal to zygotic transition & RNA. The author has an hindex of 47, co-authored 98 publications receiving 8808 citations. Previous affiliations of Howard D. Lipshitz include University of Guelph & California Institute of Technology.
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Journal ArticleDOI
A compendium of RNA-binding motifs for decoding gene regulation
Debashish Ray,Hilal Kazan,Kate B. Cook,Matthew T. Weirauch,Matthew T. Weirauch,Hamed S. Najafabadi,Xiao Li,Serge Gueroussov,Mihai Albu,Hong Zheng,Ally Yang,Hong Na,Manuel Irimia,Leah H. Matzat,Ryan K. Dale,Sarah A. Smith,Christopher A. Yarosh,Seth M. Kelly,Behnam Nabet,D. Mecenas,Weimin Li,Rakesh S. Laishram,Mei Qiao,Howard D. Lipshitz,Fabio Piano,Anita H. Corbett,Russ P. Carstens,Brendan J. Frey,Richard A. Anderson,Kristen W. Lynch,Luiz O. F. Penalva,Elissa P. Lei,Andrew G. Fraser,Benjamin J. Blencowe,Quaid Morris,Timothy P. Hughes +35 more
TL;DR: A systematic analysis of the RNA motifs recognized by RNA-binding proteins, encompassing 205 distinct genes from 24 diverse eukaryotes, provides an unprecedented overview of RNA- binding proteins and their targets, and constitute an invaluable resource for determining post-transcriptional regulatory mechanisms in eukARYotes.
Journal ArticleDOI
The maternal-to-zygotic transition: a play in two acts
Wael Tadros,Howard D. Lipshitz +1 more
TL;DR: The maternal-to-zygotic transition (MZT) has been extensively studied in model organisms, including echinoderms, nematodes, insects, fish, amphibians and mammals.
Journal ArticleDOI
Vectors for Drosophila P-element-mediated transformation and tissue culture transfection.
TL;DR: Nine P-element vectors that can be used to study gene regulation and function in Drosophila are described, designed for use in germline transformation and cell culture transfection assays.
Journal ArticleDOI
RNA Localization in Development
TL;DR: This review considers RNA localization in the context of animal development with a focus on mRNAs and non-protein-coding RNAs localized in Drosophila, Xenopus, ascidian, zebrafish, and echinoderm oocytes and embryos.
Journal ArticleDOI
SMAUG Is a Major Regulator of Maternal mRNA Destabilization in Drosophila and Its Translation Is Activated by the PAN GU Kinase
Wael Tadros,Aaron L. Goldman,Tomas Babak,Fiona Menzies,Leah A. Vardy,Terry L. Orr-Weaver,Timothy P. Hughes,J. Timothy Westwood,Craig A. Smibert,Howard D. Lipshitz +9 more
TL;DR: Microarray-based gene expression profiling shows that SMG is a major regulator of maternal transcript destabilization, and a possible causal relationship between failure to eliminate these transcripts and the cell cycle defects in smg mutants is suggested.