Hilal Kazan

TL;DR: A systematic analysis of the RNA motifs recognized by RNA-binding proteins, encompassing 205 distinct genes from 24 diverse eukaryotes, provides an unprecedented overview of RNA- binding proteins and their targets, and constitute an invaluable resource for determining post-transcriptional regulatory mechanisms in eukARYotes.

TL;DR: The RNA-Binding Protein DataBase (RBPDB) is a collection of experimental observations of RNA-binding sites, both in vitro and in vivo, manually curated from primary literature, which contains binding data on 272 RBPs.

TL;DR: Using in vitro and in vivo binding data, it is demonstrated that preferences for individual 7-mers identified by RNAcompete are a more accurate representation of binding activity than are conventional motif models.

TL;DR: Findings identify important regulatory functions of LIN28 via direct mRNA interactions through crosslinking and immunoprecipitation coupled with high-throughput sequencing in human embryonic stem cells and somatic cells expressing exogenous LIN28.

TL;DR: It is demonstrated that RNAcontext identifies known binding preferences for several control proteins including HuR, PTB, and Vts1p and predicts new RNA structure preferences for SF2/ASF, RBM4, FUSIP1 and SLM2.