Howard N. Hodis

TL;DR: The effects of treatment with a thiazolidinedione drug on rates of progression of carotid intima-media thickness (CIMT) and some putative determinants of CIMT in young women at high risk for type 2 diabetes were tested and Troglitazone reduced the progression of subclinical Atherosclerosis via a mechanism that involved unmeasured mediators of atherosclerosis.

TL;DR: Increased inflammation and hemostasis are associated with subclinical atherosclerosis in recently treated women and have potential implications for long-term risk of cardiovascular disease in HIV-infected patients, even with effective therapy.

TL;DR: This association not only suggests that certain risk factors may act early and others late in the athersclerotic process, but that triglyceride-rich lipoproteins are associated with progression of the lesions (mild/moderate lesions) which are predominantly responsible for clinical coronary events.

TL;DR: A major difference in the effects of hormones between younger and older women has emerged but this important finding has been minimized, and the final findings for all outcomes closely resemble those from observational cohorts.

TL;DR: The literature indicates similar benefit of postmenopausal hormone therapy, in women who initiate hormone therapy in close proximity to menopause, to other medications used for the primary prevention of coronory heart disease in women.